Department of Obstetrics and Gynecology, Amir-al-Momenin Hospital, Faculty of Medicine, Semnan University of Medical Sciences, Semnan, Iran.
Int J Gynaecol Obstet. 2012 Apr;117(1):45-7. doi: 10.1016/j.ijgo.2011.11.019. Epub 2012 Jan 17.
To examine whether dietary supplementation with omega-3 fatty acids relieved symptoms of primary dysmenorrhea.
Women aged 18-22 years with primary dysmenorrhea were enrolled in a double-blind crossover study. Women assigned to group 1 (n=47) received 1 omega-3 capsule daily for 3 months, followed by placebo for 3 months. Women in group 2 (n=48) received placebo for 3 months, followed by omega-3 for 3 months. A washout period was performed in both groups. Participants used 400mg of ibuprofen as a rescue dose if severe menstrual pains were experienced.
A marked reduction in pain intensity was observed after 3 months of treatment with omega-3 fatty acids (P<0.05). Women who received omega-3 fatty acids required fewer rescue doses than women who received placebo (P<0.05). The mean numbers of ibuprofen tablets used after 3 months with omega-3 fatty acids were 4.3±2.1 (group 1) and 3.2±2.5 (group 2); the mean numbers of tablets used after 3 months of placebo were 5.3±2.2 (group 1) and 6.0±2.6 (group 2) (P=0.001 for both).
Supplementation with omega-3 fatty acids reduced the symptom intensity of primary dysmenorrhea. Supplementation efficacy was sufficient to decrease the ibuprofen rescue dose.
研究ω-3 脂肪酸补充剂是否能缓解原发性痛经的症状。
将 18-22 岁的原发性痛经女性纳入双盲交叉研究。第 1 组（n=47）的女性每天服用 1 粒 ω-3 胶囊，持续 3 个月，然后服用安慰剂 3 个月。第 2 组（n=48）的女性服用安慰剂 3 个月，然后服用 ω-3 3 个月。两组均进行洗脱期。如果出现严重的月经痛，参与者使用 400mg 布洛芬作为解救剂量。
ω-3 脂肪酸治疗 3 个月后，疼痛强度明显降低（P<0.05）。服用 ω-3 脂肪酸的女性比服用安慰剂的女性需要更少的解救剂量（P<0.05）。服用 ω-3 脂肪酸 3 个月后，布洛芬片的平均用量为 4.3±2.1（第 1 组）和 3.2±2.5（第 2 组）；服用安慰剂 3 个月后，布洛芬片的平均用量为 5.3±2.2（第 1 组）和 6.0±2.6（第 2 组）（均 P=0.001）。
ω-3 脂肪酸补充剂可降低原发性痛经的症状强度。补充效果足以减少布洛芬的解救剂量。
