可能患有阿尔茨海默病患者的视觉与听觉记忆刺激。一项使用18氟脱氧葡萄糖的正电子发射断层显像研究。

Visual versus auditory memory stimulation in patients with probable Alzheimer's disease. A PET study with 18 FDG.

作者信息

Kessler J, Ghaemi M, Mielke R, Herholz K, Heiss W D

机构信息

Max-Planck Institut für neurologische Forshung and Neurologische, Universitätsklinik, Köln, Germany.

出版信息

Ann N Y Acad Sci. 1996 Jan 17;777:233-8. doi: 10.1111/j.1749-6632.1996.tb34424.x.

DOI:10.1111/j.1749-6632.1996.tb34424.x

PMID:8624090

Abstract

Patients with probable Alzheimer's disease were either stimulated with a continuous visual recognition task (n = 18) or with a continuous auditory recognition task during PET measurement with 18 FDG. The PET scanner was a Siemens CTI, ECAT EXACT with 5 mm transaxial and 6 mm axial resolution. The global stimulation effects were nearly identical in both groups and increased of 4.17 +/- 8.14% in the auditory stimulated group and of 4.03 +/- 11.78% in the visual stimulated group. Beyond regional stimulation effects in both groups a common cerebellar stimulation effect was measured. It is concluded that the cerebellar stimulation effect reflects a modality independent cognitive process and that the only small enhancement of global glucose metabolism indicates disturbed stimuli processes and finally explained the patient's failure in memory tasks.

摘要

患有可能的阿尔茨海默病的患者在使用18氟脱氧葡萄糖进行正电子发射断层扫描（PET）测量期间，要么接受连续视觉识别任务刺激（n = 18），要么接受连续听觉识别任务刺激。PET扫描仪是西门子CTI ECAT EXACT，其横向分辨率为5毫米，轴向分辨率为6毫米。两组的整体刺激效果几乎相同，听觉刺激组增加了4.17±8.14%，视觉刺激组增加了4.03±11.78%。除了两组的局部刺激效果外，还测量到了共同的小脑刺激效果。得出的结论是，小脑刺激效果反映了一种与模式无关的认知过程，而整体葡萄糖代谢的唯一小幅增强表明刺激过程受到干扰，最终解释了患者在记忆任务中的失败。