McIntyre K M, Sasahara A A
Chest. 1977 Jun;71(6):692-7. doi: 10.1378/chest.71.6.692.
The magnitude of embolic obstruction by pulmonary angiographic studies has been shown to be directly related to the hemodynamic status after pulmonary embolism in patients free of prior cardiopulmonary disease; however, in patients with prior cardiopulmonary disease, the hemodynamic status after embolism may be determined either by the preembolic hemodynamic status, the magnitude of embolic obstruction, or both. No reliable index has been available to help determine the relative roles of embolism and preembolic hemodynamic disturbances in the postembolic hemodynamic status. The present study suggests that the ratio of the mean pulmonary arterial pressure to the pulmonary angiographic obstruction may effectively distinguish those patients in whom pulmonary embolism is the primary determinant of the postembolic hemodynamic abnormality from those in whom the preembolic hemodynamic abnormalities play the dominant role.
对于无既往心肺疾病的患者,肺血管造影研究显示,栓塞阻塞的程度与肺栓塞后的血流动力学状态直接相关;然而,对于有既往心肺疾病的患者,栓塞后的血流动力学状态可能由栓塞前的血流动力学状态、栓塞阻塞的程度或两者共同决定。目前尚无可靠指标可用于确定栓塞和栓塞前血流动力学紊乱在栓塞后血流动力学状态中的相对作用。本研究表明,平均肺动脉压与肺血管造影阻塞程度之比可有效区分肺栓塞是栓塞后血流动力学异常的主要决定因素的患者和栓塞前血流动力学异常起主导作用的患者。