Schmidt E, Bruch H P, Walter K
Chirurg. 1977 Apr;48(4):254-5.
Prostaglandins (E1, E2, F2alpha) produce and intensify peristaltic contractions in the healthy human intestinal muscle system according to dosage (threshold I-10(-4) microng/ml--maximum effective concentration 1 microng/ml). By subsequent introduction of adrenaline, the intestinal muscle system activated by prostaglandines can be completely relaxed again. Intestinal muscles from patients with Crohn's disease show a marked deviation from this behaviour: 1. The intestinal muscle system is extremely sensitive to prostagladins: maximum concentrations are already reached by about a thousand times smaller concentration than in the intestines. 2. The dose of adrenaline does not lead to dialtion, which is usual, but to contraction of the muscle system. These changes in the contractility of the intestine can explain some components of the clinical symptomatology of Crohn's disease.
前列腺素（E1、E2、F2α）可根据剂量（阈值I - 10(-4)微克/毫升 - 最大有效浓度1微克/毫升）在健康人体肠道肌肉系统中产生并增强蠕动收缩。随后引入肾上腺素后，由前列腺素激活的肠道肌肉系统可再次完全松弛。克罗恩病患者的肠道肌肉表现出与此行为明显不同：1. 肠道肌肉系统对前列腺素极为敏感：达到最大浓度时所需的浓度比正常肠道小约一千倍。2. 肾上腺素的剂量不会导致通常出现的舒张，而是导致肌肉系统收缩。肠道收缩性的这些变化可以解释克罗恩病临床症状学的一些组成部分。
