Wetherill P E, Landry M L, Alcabes P, Friedland G
AIDS Program, Department of Medicine, Yale University School of Medicine, New Haven, Connecticut 06510-2483, USA.
J Acquir Immune Defic Syndr Hum Retrovirol. 1996 May 1;12(1):33-7. doi: 10.1097/00042560-199605010-00005.
Cytomegalovirus (CMV) infection remains a life-threatening infection in patients with HIV disease. A rapid, quantitative diagnostic technique is needed to adi in the diagnosis of CMV disease. This study was undertaken to evaluate the CMV antigenemia test in patients with HIV disease who are at risk for CMV disease. The study included 22 patients who underwent ophthalmologic exams or selected diagnostic techniques in whom CMV cultures and CMV antigenemia tests were performed. All of 11 patients with CMV disease had positive CMV antigenemia assays [range, 48-1,000 positive cells/2 x 10(5) peripheral blood leukocytes (PBL)], and 10 were also CMV viremic. There was no clinical evidence of CMV disease in 11 patients, including seven in whom the CMV antigenemia assay was negative and who remained without evidence of CMV disease after a median follow-up of 159 days. Four patients had low antigenemia levels. Of these four, two subsequently developed CMV retinitis. In conclusion, a positive CMV antigenemia result with > or = 48 positive cells/2 x 10(5) PBL correlated with concurrent CMV disease. The CMV antigenemia test appears to be a valuable tool for the rapid diagnosis of CMV disease in HIV-infected individuals.
巨细胞病毒（CMV）感染在艾滋病患者中仍然是一种危及生命的感染。需要一种快速、定量的诊断技术来辅助诊断CMV疾病。本研究旨在评估CMV抗原血症检测在有CMV疾病风险的艾滋病患者中的应用。该研究纳入了22例接受眼科检查或选定诊断技术的患者，对其进行了CMV培养和CMV抗原血症检测。11例患有CMV疾病的患者CMV抗原血症检测均呈阳性[范围为48 - 1000个阳性细胞/2×10⁵外周血白细胞（PBL）]，其中10例同时存在CMV病毒血症。11例患者无CMV疾病的临床证据，包括7例CMV抗原血症检测为阴性的患者，在中位随访159天后仍无CMV疾病证据。4例患者抗原血症水平较低。这4例患者中，2例随后发生了CMV视网膜炎。总之，CMV抗原血症结果≥48个阳性细胞/2×10⁵ PBL与同时存在的CMV疾病相关。CMV抗原血症检测似乎是快速诊断HIV感染个体CMV疾病的一种有价值的工具。
