肥厚型心肌病中心肌β肾上腺素能受体与左心室功能
Myocardial beta adrenoceptors and left ventricular function in hypertrophic cardiomyopathy.
作者信息
Choudhury L, Guzzetti S, Lefroy D C, Nihoyannopoulos P, McKenna W J, Oakley C M, Camici P G
机构信息
MRC Clinical Sciences Centre, Hammersmith Hospital, London.
出版信息
Heart. 1996 Jan;75(1):50-4. doi: 10.1136/hrt.75.1.50.
OBJECTIVE
To assess the relation between left ventricular function and myocardial beta adrenoceptor density.
METHODS
17 patients with hypertrophic cardiomyopathy, six with and 11 without heart failure, were studied. Left ventricular function was assessed by echocardiography, and myocardial beta adrenoceptors by positron emission tomography. Patient data were compared with those obtained in normal controls.
RESULTS
Myocardial beta adrenoceptor density in the 17 patients was 7.00 (SD 1.90) pmol/g v 11.50 (2.18) pmol/g in normal controls (P < 0.01). beta Adrenoceptor density in the six patients with left ventricular failure was 5.61 (0.88) pmol/g v 7.71 (1.86) pmol/g in the 11 patients with normal ventricular function (P < 0.05), and there was a significant correlation (r = 0.52; P < 0.05) between left ventricular fractional shortening and myocardial beta adrenoceptor density. A positive correlation (r = 0.51; P < 0.05) was also found between myocardial beta adrenoceptor density and the E/A transmitral flow ratio, an index of left ventricular diastolic function.
CONCLUSIONS
There is myocardial beta adrenoceptor downregulation in patients with hypertrophic cardiomyopathy with or without signs of heart failure.
目的
评估左心室功能与心肌β肾上腺素能受体密度之间的关系。
方法
对17例肥厚型心肌病患者进行研究，其中6例有心力衰竭，11例无心力衰竭。通过超声心动图评估左心室功能，通过正电子发射断层扫描评估心肌β肾上腺素能受体。将患者数据与正常对照组的数据进行比较。
结果
17例患者的心肌β肾上腺素能受体密度为7.00（标准差1.90）pmol/g，而正常对照组为11.50（2.18）pmol/g（P<0.01）。6例左心室衰竭患者的β肾上腺素能受体密度为5.61（0.88）pmol/g，而11例心室功能正常患者为7.71（1.86）pmol/g（P<0.05），左心室缩短分数与心肌β肾上腺素能受体密度之间存在显著相关性（r=0.52；P<0.05）。心肌β肾上腺素能受体密度与E/A二尖瓣血流比值（左心室舒张功能指标）之间也存在正相关性（r=0.51；P<0.05）。
结论
有或无心力衰竭迹象的肥厚型心肌病患者存在心肌β肾上腺素能受体下调。
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