Mereto E, Ghia M, Brambilla G
Istituto de Farmacologia dell'Università, Genova, Italy.
Cancer Lett. 1996 Mar 19;101(1):79-83. doi: 10.1016/0304-3835(96)04129-8.
Anthraquinone glycosides of Senna and Cascara were investigated for their ability to induce aberrant crypt foci (ACF) in the rat colon mucosa, which are considered putative preneoplastic lesions. Dietary exposure to high doses of these glycosides for 56 successive days did not cause the appearance of ACF or increase in incidence of ACF induced by 1,2-dimethyl-hydrazine (DMH). However, in rats treated with both DMH and the highest dose of glycosides, the average number of aberrant crypts per focus, considered a consistent predictor of tumor outcome, was higher than in rats given DMH alone. These findings suggest that Senna and Cascara glycoside might behave as weak promoters in rat colon carcinogenesis.
研究了番泻叶和鼠李皮中的蒽醌苷诱导大鼠结肠黏膜中异常隐窝灶（ACF）的能力，ACF被认为是假定的癌前病变。连续56天饮食中高剂量接触这些苷类不会导致ACF出现，也不会增加由1,2 - 二甲基肼（DMH）诱导的ACF发生率。然而，在同时用DMH和最高剂量苷类处理的大鼠中，每个病灶中异常隐窝的平均数量（这被认为是肿瘤发生结果的一个一致预测指标）高于仅给予DMH的大鼠。这些发现表明，番泻叶和鼠李皮苷在大鼠结肠癌发生过程中可能表现为弱促癌剂。
