Le Jiamei, Ji Houlin, Zhou Xiaoxiao, Wei Xindong, Chen Yifan, Fu Yi, Ma Yujie, Han Qiuqin, Sun Yongning, Gao Yueqiu, Wu Hailong
Shanghai University of Medicine & Health Sciences Affiliated Zhoupu Hospital, Shanghai, China.
Shanghai Key Laboratory of Molecular Imaging, Collaborative Innovation Center for Biomedicine, Shanghai University of Medicine and Health Sciences, Shanghai, China.
Front Pharmacol. 2021 Oct 26;12:714586. doi: 10.3389/fphar.2021.714586. eCollection 2021.
Sennoside A (SA) is a natural dianthrone glycoside mainly from medicinal plants of Senna and Rhubarb, and used as a folk traditional irritant laxative and slimming health food. Accumulating evidences suggest that SA possesses numerous pharmacological properties, such as laxative, anti-obesity, hypoglycemic, hepatoprotective, anti-fibrotic, anti-inflammatory, anti-tumor, anti-bacterial, anti-fungal, anti-viral, and anti-neurodegenerative activities. These pharmacological effects lay the foundation for its potential application in treating a variety of diseases. However, numerous published studies suggest that a long-term use of SA in large doses may have some adverse effects, including the occurrence of melanosis coli and carcinogenesis of colon cancer, thereby limiting its clinical use. It remains to be established whether SA or its metabolites are responsible for the pharmacological and toxicity effects. In this review, the latest advances in the pharmacology, toxicology, and metabolism of SA were summarizedbased on its biological characteristics and mechanism.
番泻苷A（SA）是一种天然二蒽酮苷，主要来源于番泻叶和大黄等药用植物，用作民间传统刺激性泻药和减肥保健食品。越来越多的证据表明，SA具有多种药理特性，如通便、抗肥胖、降血糖、保肝、抗纤维化、抗炎、抗肿瘤、抗菌、抗真菌、抗病毒和抗神经退行性活性。这些药理作用为其在治疗多种疾病中的潜在应用奠定了基础。然而，大量已发表的研究表明，长期大剂量使用SA可能会产生一些不良反应，包括结肠黑变病的发生和结肠癌的致癌作用，从而限制了其临床应用。SA或其代谢产物是否对药理和毒性作用负责仍有待确定。在这篇综述中，基于SA的生物学特性和机制，总结了其药理学、毒理学和代谢方面的最新进展。
