Harrison J B, Chen H H, Sattelle E, Barker P J, Huskisson N S, Rauh J J, Bai D, Sattelle D B
Babraham Institute Laboratory of Molecular Signalling, Cambridge, UK.
Cell Tissue Res. 1996 May;284(2):269-78. doi: 10.1007/s004410050587.
An antibody raised against a peptide based on the C-terminal derived amino acid sequence from a cloned Drosophila melanogaster (fruit fly) gene, Rdl (resistant to dieldrin), was used to investigate localization of a GABA receptor subunit in adult male D. melanogaster. Many regions in the brain and thoracic ganglia were stained with this antibody. For example, staining was detected in the medulla, lobula and lobular plate optic neurpiles. Also stained were the antennal lobe glomeruli, the ellipsoid body of the central complex and the mushroom bodies. These results suggest possible roles for an RDL-like GABA receptor subunit in the processing of olfactory, visual and mechanosensory information in the nervous system of D. melanogaster.
一种针对基于克隆的黑腹果蝇（果蝇）基因Rdl（对狄氏剂抗性）的C末端衍生氨基酸序列的肽产生的抗体，用于研究成年雄性黑腹果蝇中GABA受体亚基的定位。大脑和胸神经节的许多区域都被这种抗体染色。例如，在髓质、小叶和小叶板视神经纤维网中检测到染色。触角叶小球、中央复合体的椭球体和蘑菇体也被染色。这些结果表明，RDL样GABA受体亚基可能在黑腹果蝇神经系统的嗅觉、视觉和机械感觉信息处理中发挥作用。
