Botto M, Theodoridis E, Thompson E M, Beynon H L, Briggs D, Isenberg D A, Walport M J, Davies K A
Department of Medicine, RPMS, Hammersmith Hospital, London, UK.
Clin Exp Immunol. 1996 May;104(2):264-8. doi: 10.1046/j.1365-2249.1996.33740.x.
An allotypic variant of Fc gamma RIIa, Fc gamma RIIa-HR (Fc gamma RIIa-R131), has been shown in vitro to reduce the capacity of phagocytic cells to bind and internalize IgG-containing immune complexes. Our aim was to determine whether this allotypic variant was associated with susceptibility to SLE and the development of lupus nephritis, as previous studies have suggested. Fc gamma RIIA genotype analysis was performed by amplification refractory mutation system-polymerase chain reaction (ARMS-PCR) in 215 Caucasoid, 70 Afro-Caribbean, and 46 Chinese patients with SLE, and in 259,77 and 49 ethnically matched controls, respectively. Distribution of Fc gamma RIIa genotypes between the patients and ethnically matched controls was not significantly different in the three populations studied. No association between the Fc gamma RIIa-HR allotype and nephritis was found. Our results suggest that the Fc gamma RIIa-HR allotype is not a major factor predisposing to the development of SLE, or to lupus nephritis.
FcγRIIa的一种同种异型变体，即FcγRIIa-HR（FcγRIIa-R131），已在体外实验中被证实会降低吞噬细胞结合和内化含IgG免疫复合物的能力。正如先前研究表明的那样，我们的目的是确定这种同种异型变体是否与系统性红斑狼疮（SLE）易感性及狼疮性肾炎的发生有关。通过扩增阻滞突变系统-聚合酶链反应（ARMS-PCR）分别对215名白种人、70名非洲裔加勒比人和46名中国SLE患者，以及259名、77名和49名种族匹配的对照进行FcγRIIA基因型分析。在所研究的三个群体中，患者与种族匹配对照之间的FcγRIIa基因型分布无显著差异。未发现FcγRIIa-HR同种异型与肾炎之间存在关联。我们的结果表明，FcγRIIa-HR同种异型不是导致SLE或狼疮性肾炎发生的主要因素。
