Smyth L J, Snowden N, Carthy D, Papasteriades C, Hajeer A, Ollier W E
ARC Epidemiology Unit, University of Manchester.
Ann Rheum Dis. 1997 Dec;56(12):744-6. doi: 10.1136/ard.56.12.744.
Polymorphism of the phagocyte IgG receptor Fc gamma RIIa may modulate immune complex mediated inflammation, particularly when immune complexes contain IgG2. Previous studies suggest that this polymorphism may be an important risk factor for lupus nephritis. Fc gamma RIIa is biallelic, the alleles R and H each having a gene frequency of about 50%. Nephritis has been associated with an increased frequency of the R allele. The frequency of common Fc gamma RIIa alleles was examined in white subjects from the United Kingdom and Greek subjects with systemic lupus erythematosus (SLE) and healthy controls.
Fc gamma RIIa genotyping was performed using a single step polymerase chain reaction technique, which differentiates the two major alleles, R and H. Two study populations were examined: (a) white subjects from the United Kingdom: 66 controls and 81 with SLE (19 of whom had renal disease) and (b) Greek: 52 controls and 42 with SLE (19 with renal disease).
No significant relation was observed between Fc gamma RIIa genotype and susceptibility to SLE or SLE nephritis.
The Fc gamma RIIa R allele does not seem to be associated with SLE (with or without renal disease) in our United Kingdom white or Greek populations.
吞噬细胞IgG受体FcγRIIa的多态性可能会调节免疫复合物介导的炎症，特别是当免疫复合物含有IgG2时。先前的研究表明，这种多态性可能是狼疮性肾炎的一个重要危险因素。FcγRIIa是双等位基因，等位基因R和H的基因频率均约为50%。肾炎与R等位基因频率增加有关。对来自英国的白人受试者以及患有系统性红斑狼疮（SLE）的希腊受试者和健康对照者中常见的FcγRIIa等位基因频率进行了检测。
采用单步聚合酶链反应技术进行FcγRIIa基因分型，该技术可区分两个主要等位基因R和H。检测了两个研究人群：（a）来自英国的白人受试者：66名对照者和81名SLE患者（其中19人患有肾脏疾病）；（b）希腊人：52名对照者和42名SLE患者（19人患有肾脏疾病）。
未观察到FcγRIIa基因型与SLE或SLE肾炎易感性之间存在显著关联。
在我们研究的英国白人或希腊人群中，FcγRIIa R等位基因似乎与SLE（无论有无肾脏疾病）无关。
