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10
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整合宿主因子通过解除IclR的抑制作用来增强大肠杆菌aceBAK操纵子的诱导。

Integration host factor amplifies the induction of the aceBAK operon of Escherichia coli by relieving IclR repression.

作者信息

Resnik E, Pan B, Ramani N, Freundlich M, LaPorte D C

机构信息

Department of Biochemistry, University of Minnesota, Minneapolis 55455, USA.

出版信息

J Bacteriol. 1996 May;178(9):2715-7. doi: 10.1128/jb.178.9.2715-2717.1996.

DOI:10.1128/jb.178.9.2715-2717.1996
PMID:8626344
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC178001/
Abstract

A binding site for integration host factor (IHF) was identified upstream of the aceBAK promoter. Under inducing conditions, IHF activates aceB::lacZ expression by opposing IclR repression. In contrast, IHF has little effect on aceB::lacZ expression under repressing conditions. The ability of IHF to relieve repression under inducing but not repressing conditions allows this protein to amplify the induction of aceBAK.

摘要

在aceBAK启动子上游鉴定出了整合宿主因子（IHF）的一个结合位点。在诱导条件下，IHF通过对抗IclR的抑制作用来激活aceB::lacZ的表达。相比之下，在抑制条件下IHF对aceB::lacZ的表达几乎没有影响。IHF在诱导而非抑制条件下解除抑制的能力使得该蛋白能够增强aceBAK的诱导作用。