Fachet J, Andó I
Eur J Immunol. 1977 Apr;7(4):223-6. doi: 10.1002/eji.1830070407.
Delayed-type hypersensitivity (DTH) to 2-phenyl-4-ethoxymethylene-5-oxazolone (oxazolone) was found to be under multigenic control in inbred, H-2 congenic and intra-H-2 recombinant strains of mice. A high response was associated with haplotypes H-2d,a,k and low response with haplotype H-2b. DTH to oxazolone was high or intermediate in different F1 hybrids of high and low responder mice. In F2 and backcross generations a higher response was associated with the "dd", than with "bb" phenotype, while intermediate response was found in the heterozygote "db" mice. A study of H-2 recombinant strains suggests that a gene controlling the DTH response maps in the I-B subregion of the H-2 complex. The response was significantly modified by gene(s) which are not linked to the H-2 complex and have not been mapped. Since congenitally athymic nude (nu/nu) mice did not respond to oxazolone, this contact sensitivity is belived to be a T cell-dependent immune response.
在近交系、H-2 同源近交系和 H-2 内部重组小鼠品系中，发现对 2-苯基-4-乙氧基亚甲基-5-恶唑酮（恶唑酮）的迟发型超敏反应（DTH）受多基因控制。高反应性与 H-2d、a、k 单倍型相关，低反应性与 H-2b 单倍型相关。在高反应性和低反应性小鼠的不同 F1 杂种中，对恶唑酮的 DTH 反应为高或中等。在 F2 和回交世代中，“dd”表型的反应性高于“bb”表型，而杂合子“db”小鼠表现出中等反应性。对 H-2 重组品系的研究表明，控制 DTH 反应的一个基因定位于 H-2 复合体的 I-B 亚区。该反应受到与 H-2 复合体不连锁且尚未定位的基因的显著影响。由于先天性无胸腺裸鼠（nu/nu）对恶唑酮无反应，因此这种接触敏感性被认为是一种 T 细胞依赖性免疫反应。
