Bigoni B, Dolcetti R, de Lellis L, Carbone A, Boiocchi M, Cassai E, Di Luca D
Institute of Microbiology, University of Ferrara, Italy.
J Infect Dis. 1996 Mar;173(3):542-9. doi: 10.1093/infdis/173.3.542.
In this study the prevalence of human herpesvirus (HHV) 8 DNA was determined in biopsies from persons with lymphoproliferative disorders and in peripheral blood mononuclear cells (PBMC) from human immunodeficiency virus (HIV)-seronegative and HIV-infected persons. The results show that HHV-8 is present in 10% of biopsies from HIV-seronegative persons: HHV-8 is detected with similar prevalence values in HIV-infected patients with lymphoproliferative diseases, but the virus load is higher. HHV-8 was also found in PBMC. The presence of monoclonal Epstein-Barr virus (EBV) genomes in malignant lymphoproliferations was only infrequently associated with HHV-8 infection. Therefore, HHV-8 is fairly common in the population, and the lymphoid system could represent a reservoir of latently infected cells from which the virus may reactivate in conditions of immunodepression; furthermore, HHV-8 and EBV do not seem to act in conjunction in lymphomagenesis.
在本研究中，测定了淋巴增殖性疾病患者活检组织以及人类免疫缺陷病毒（HIV）血清阴性和HIV感染个体外周血单个核细胞（PBMC）中人类疱疹病毒（HHV）8型DNA的流行情况。结果显示，HHV-8存在于10%的HIV血清阴性个体的活检组织中：在患有淋巴增殖性疾病的HIV感染患者中检测到的HHV-8流行率相似，但病毒载量更高。在PBMC中也发现了HHV-8。恶性淋巴增殖中存在单克隆爱泼斯坦-巴尔病毒（EBV）基因组与HHV-8感染仅偶尔相关。因此，HHV-8在人群中相当常见，淋巴系统可能是潜伏感染细胞的储存库，在免疫抑制条件下病毒可能从中重新激活；此外，HHV-8和EBV在淋巴瘤发生过程中似乎并非协同作用。
