Iwasaki T, Hashimoto N, Endoh D, Imanisi T, Itakura C, Sato F
Faculty of Veterinary Medicine, Hokkaido University, Sapporo, Japan.
Int J Radiat Biol. 1996 Apr;69(4):487-92. doi: 10.1080/095530096145788.
C57BL/6 male mice were exposed to 3 Gy 60Co gamma-rays and mated with unirradiated females after 15 days to produce F1 progeny produced following irradiation of the spermatids. After weaning the offsprings were allowed to live their normal life span. The mean litter size of the irradiated group significantly decreased from 7.1 to 4.9 (p < 0.01), but the sex ratio was not altered by the irradiation. No significant differences in the survival curve and mean life-span between the irradiated and control groups were noted. The only radiation effect in tumour incidence was a decrease of histiocytic sarcoma in female offspring of irradiated males. Except for this, there were no significant differences between the irradiated group and the control group in the incidence or age distribution of tumours.
将C57BL/6雄性小鼠暴露于3 Gy的60Coγ射线，15天后与未受辐照的雌性小鼠交配，以产生精子细胞受辐照后产生的F1代后代。断奶后，让后代正常生活至其自然寿命。辐照组的平均窝仔数从7.1显著下降至4.9（p<0.01），但辐照并未改变性别比例。辐照组和对照组之间的生存曲线和平均寿命无显著差异。肿瘤发生率方面唯一的辐射效应是辐照雄性小鼠的雌性后代中组织细胞肉瘤减少。除此之外，辐照组和对照组在肿瘤发生率或年龄分布上没有显著差异。
