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Possible role of GABA in the development of tolerance to alcohol.

作者信息

Leitch G J, Backes D J, Siegman F S, Guthrie G D

出版信息

Experientia. 1977 Apr 15;33(4):496-8. doi: 10.1007/BF01922232.

DOI:10.1007/BF01922232
PMID:862744
Abstract
摘要

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Possible role of GABA in the development of tolerance to alcohol.γ-氨基丁酸在酒精耐受性发展中的可能作用。
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Effects of GABA blockade on lateral hypothalamic self-stimulation.γ-氨基丁酸阻断对下丘脑外侧自我刺激的影响。
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Motor activity of rats following intracerebral injections of drugs influencing GABA mechanisms.脑内注射影响γ-氨基丁酸（GABA）机制的药物后大鼠的运动活动
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The striatal dopaminergic function is mediated by the inhibition of a nigral, non-dopaminergic neuronal system via a strio-nigral GABAergic pathway.纹状体多巴胺能功能是通过纹状体-黑质γ-氨基丁酸能通路对黑质非多巴胺能神经元系统的抑制作用来介导的。
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Antagonism of diazepam against central anticholinergic drug-induced hyperactivity in mice: involvement of a GABA mechanism.地西泮对中枢抗胆碱能药物诱发小鼠活动亢进的拮抗作用：γ-氨基丁酸机制的参与
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Rotational behaviour after unilateral intranigral injection of muscimol in rats.大鼠单侧黑质内注射蝇蕈醇后的旋转行为
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Pharmacological manipulation of gamma-aminobutyric acid (GABA) in morphine analgesia, tolerance and physical dependence.
Life Sci. 1976 May 15;18(10):1111-23. doi: 10.1016/0024-3205(76)90146-6.
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gamma-aminobutyric acid in alcohol, barbiturate and morphine dependence: a review.
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Physiology and pharmacology of alcohol: the imidazobenzodiazepine alcohol antagonist site on subtypes of GABAA receptors as an opportunity for drug development?酒精的生理学与药理学：GABAA受体亚型上的咪唑并苯二氮䓬类酒精拮抗剂位点——药物研发的契机？
Br J Pharmacol. 2008 May;154(2):288-98. doi: 10.1038/bjp.2008.32. Epub 2008 Feb 18.
2
Similar effects of ethanol and flumazenil on acquisition of a shuttle-box avoidance response during withdrawal from chronic ethanol treatment.乙醇和氟马西尼对慢性乙醇治疗戒断期间穿梭箱回避反应习得的类似影响。
Br J Pharmacol. 1993 Oct;110(2):753-60. doi: 10.1111/j.1476-5381.1993.tb13876.x.
3

本文引用的文献

1
Protein measurement with the Folin phenol reagent.使用福林酚试剂进行蛋白质测定。
J Biol Chem. 1951 Nov;193(1):265-75.
2
The effect of ethanol on GABA content of rat brain.乙醇对大鼠脑内γ-氨基丁酸含量的影响。
Biochem Pharmacol. 1962 Apr-May;11:394-5. doi: 10.1016/0006-2952(62)90063-1.
3
Studies on the GABA pathway. I. The inhibition of gamma-aminobutyric acid-alpha-ketoglutaric acid transaminase in vitro and in vivo by U-7524 (amino-oxyacetic acid).γ-氨基丁酸通路的研究。I. U-7524（氨氧基乙酸）对体外和体内γ-氨基丁酸-α-酮戊二酸转氨酶的抑制作用。
Attenuation of the effects of punishment by ethanol: comparisons with chlordiazepoxide.
Psychopharmacology (Berl). 1980;71(2):123-9. doi: 10.1007/BF00434399.
4
Acute and chronic ethanol administration on specific 3H-GABA binding in different rat brain areas.急性和慢性给予乙醇对大鼠不同脑区特异性3H-γ-氨基丁酸结合的影响
Psychopharmacology (Berl). 1980;67(3):261-4. doi: 10.1007/BF00431267.
5
The effects of neurotensin, beta-endorphin, and bombesin on ethanol-induced behaviors in mice.神经降压素、β-内啡肽和蛙皮素对小鼠乙醇诱导行为的影响。
Psychopharmacology (Berl). 1983;79(4):357-63. doi: 10.1007/BF00433418.
6
GABAergic modulation of ethanol-induced motor impairment.乙醇诱导的运动障碍的γ-氨基丁酸能调节
J Pharmacol Exp Ther. 1982 Dec;223(3):750-6.
7
An evaluation of the selectivity of fenmetozole (DH-524) reversal of ethanol-induced changes in central nervous system function.对芬美唑（DH - 524）逆转乙醇诱导的中枢神经系统功能变化的选择性评估。
Psychopharmacology (Berl). 1980;69(2):149-55. doi: 10.1007/BF00427641.
8
The effects of acute and chronic ethanol administration and its withdrawal on gamma-aminobutyric acid receptor binding in rat brain.急性和慢性给予乙醇及其戒断对大鼠脑内γ-氨基丁酸受体结合的影响。
Br J Pharmacol. 1980 Nov;70(3):403-10. doi: 10.1111/j.1476-5381.1980.tb08716.x.
9
Glutamate, GABA, and CNS disease: a review.谷氨酸、γ-氨基丁酸与中枢神经系统疾病：综述
Neurochem Res. 1983 Apr;8(4):521-50. doi: 10.1007/BF00965107.
Biochem Pharmacol. 1961 Feb;5:323-31. doi: 10.1016/0006-2952(61)90023-5.
4
The effect of ethanol on the amino acids of the rat brain with a reference to the administration of glutamine.乙醇对大鼠脑氨基酸的影响，并参考谷氨酰胺的给药情况。
Biochem J. 1961 Mar;78(3):588-93. doi: 10.1042/bj0780588.
5
Soluble gamma-aminobutyric-glutamic transaminase from Pseudomonas fluorescens.来自荧光假单胞菌的可溶性γ-氨基丁酸-谷氨酸转氨酶
J Biol Chem. 1959 Apr;234(4):932-6.
6
The effect of ethanol on the concentration of gamma-aminobutyric acid in the rat brain.
Can J Physiol Pharmacol. 1967 Sep;45(5):915-8. doi: 10.1139/y67-107.
7
Reduction in brain gamma-aminobutyric acid and in barbital narcosis during ethanol withdrawal.
J Pharmacol Exp Ther. 1973 Sep;186(3):625-9.
8
The inhibitory action of -aminobutyric acid, a probable synaptic transmitter.
Int Rev Neurobiol. 1972;15:167-87. doi: 10.1016/s0074-7742(08)60330-x.
9
Suppression of inhibition in the cerebellar cortex by picrotoxin and bicuculline.
Brain Res. 1971 May 21;28(3):591-3. doi: 10.1016/0006-8993(71)90074-6.
10
Development of an expression which relates the excitable state of the brain to the level of GAD activity and GABA content, with particular reference to the action of hydrazine and its derivatives.一种将大脑的兴奋状态与谷氨酸脱羧酶（GAD）活性水平和γ-氨基丁酸（GABA）含量联系起来的表达式的开发，特别提及肼及其衍生物的作用。
J Neurochem. 1974 Oct;23(4):703-12. doi: 10.1111/j.1471-4159.1974.tb04394.x.