2',3'-二脱氧-2',3'-二脱氢-β-L-胞苷（β-L-d4C）和2',3'-二脱氧-2',3'-二脱氢-β-L-5-氟胞苷（β-L-Fd4C）的设计与合成，这两种化合物是体外强效的人乙型肝炎病毒（HBV）抑制剂以及人免疫缺陷病毒（HIV）的强效抑制剂。 - Suppr

Suppr

超能文献

Design and synthesis of 2',3'-dideoxy-2',3'-didehydro-beta-L-cytidine (beta-L-d4C) and 2',3'-dideoxy 2',3'-didehydro-beta-L-5-fluorocytidine (beta-L-Fd4C), two exceptionally potent inhibitors of human hepatitis B virus (HBV) and potent inhibitors of human immunodeficiency virus (HIV) in vitro.

作者信息

Lin T S, Luo M Z, Liu M C, Zhu Y L, Gullen E, Dutschman G E, Cheng Y C

机构信息

Department of Pharmacology, Yale University School of Medicine, New Haven, Connecticut 06520-8066, USA.

出版信息

J Med Chem. 1996 Apr 26;39(9):1757-9. doi: 10.1021/jm950836q.

DOI:10.1021/jm950836q

PMID:8627596

Abstract

摘要

相似文献

Design and synthesis of 2',3'-dideoxy-2',3'-didehydro-beta-L-cytidine (beta-L-d4C) and 2',3'-dideoxy 2',3'-didehydro-beta-L-5-fluorocytidine (beta-L-Fd4C), two exceptionally potent inhibitors of human hepatitis B virus (HBV) and potent inhibitors of human immunodeficiency virus (HIV) in vitro.2',3'-二脱氧-2',3'-二脱氢-β-L-胞苷（β-L-d4C）和2',3'-二脱氧-2',3'-二脱氢-β-L-5-氟胞苷（β-L-Fd4C）的设计与合成，这两种化合物是体外强效的人乙型肝炎病毒（HBV）抑制剂以及人免疫缺陷病毒（HIV）的强效抑制剂。

J Med Chem. 1996 Apr 26;39(9):1757-9. doi: 10.1021/jm950836q.

Synthesis and biological evaluation of 2',3'-dideoxy-L-pyrimidine nucleosides as potential antiviral agents against human immunodeficiency virus (HIV) and hepatitis B virus (HBV).2',3'-二脱氧-L-嘧啶核苷作为抗人类免疫缺陷病毒（HIV）和乙型肝炎病毒（HBV）潜在抗病毒药物的合成及生物学评价

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Antiviral activity of 2',3'-dideoxy-beta-L-5-fluorocytidine (beta-L-FddC) and 2',3'-dideoxy-beta-L-cytidine (beta-L-ddC) against hepatitis B virus and human immunodeficiency virus type 1 in vitro.2',3'-二脱氧-β-L-5-氟胞苷（β-L-FddC）和2',3'-二脱氧-β-L-胞苷（β-L-ddC）在体外对乙型肝炎病毒和1型人类免疫缺陷病毒的抗病毒活性。

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N4-acyl-modified D-2',3'-dideoxy-5-fluorocytidine nucleoside analogues with improved antiviral activity.具有改善抗病毒活性的N4-酰基修饰的D-2',3'-二脱氧-5-氟胞苷核苷类似物。

Antivir Chem Chemother. 2003 Mar;14(2):81-90. doi: 10.1177/095632020301400203.

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