2',3'-二脱氧-2',3'-二脱氢-β-L-胞苷（β-L-d4C）和2',3'-二脱氧-2',3'-二脱氢-β-L-5-氟胞苷（β-L-Fd4C）的设计与合成，这两种化合物是体外强效的人乙型肝炎病毒（HBV）抑制剂以及人免疫缺陷病毒（HIV）的强效抑制剂。 - Suppr

Suppr

超能文献

Design and synthesis of 2',3'-dideoxy-2',3'-didehydro-beta-L-cytidine (beta-L-d4C) and 2',3'-dideoxy 2',3'-didehydro-beta-L-5-fluorocytidine (beta-L-Fd4C), two exceptionally potent inhibitors of human hepatitis B virus (HBV) and potent inhibitors of human immunodeficiency virus (HIV) in vitro.

作者信息

Lin T S, Luo M Z, Liu M C, Zhu Y L, Gullen E, Dutschman G E, Cheng Y C

机构信息

Department of Pharmacology, Yale University School of Medicine, New Haven, Connecticut 06520-8066, USA.

出版信息

J Med Chem. 1996 Apr 26;39(9):1757-9. doi: 10.1021/jm950836q.

DOI:10.1021/jm950836q

PMID:8627596

Abstract

摘要

相似文献

Design and synthesis of 2',3'-dideoxy-2',3'-didehydro-beta-L-cytidine (beta-L-d4C) and 2',3'-dideoxy 2',3'-didehydro-beta-L-5-fluorocytidine (beta-L-Fd4C), two exceptionally potent inhibitors of human hepatitis B virus (HBV) and potent inhibitors of human immunodeficiency virus (HIV) in vitro.2',3'-二脱氧-2',3'-二脱氢-β-L-胞苷（β-L-d4C）和2',3'-二脱氧-2',3'-二脱氢-β-L-5-氟胞苷（β-L-Fd4C）的设计与合成，这两种化合物是体外强效的人乙型肝炎病毒（HBV）抑制剂以及人免疫缺陷病毒（HIV）的强效抑制剂。

J Med Chem. 1996 Apr 26;39(9):1757-9. doi: 10.1021/jm950836q.

Synthesis and biological evaluation of 2',3'-dideoxy-L-pyrimidine nucleosides as potential antiviral agents against human immunodeficiency virus (HIV) and hepatitis B virus (HBV).2',3'-二脱氧-L-嘧啶核苷作为抗人类免疫缺陷病毒（HIV）和乙型肝炎病毒（HBV）潜在抗病毒药物的合成及生物学评价

J Med Chem. 1994 Mar 18;37(6):798-803. doi: 10.1021/jm00032a013.

Antiviral activity of 2',3'-dideoxy-beta-L-5-fluorocytidine (beta-L-FddC) and 2',3'-dideoxy-beta-L-cytidine (beta-L-ddC) against hepatitis B virus and human immunodeficiency virus type 1 in vitro.2',3'-二脱氧-β-L-5-氟胞苷（β-L-FddC）和2',3'-二脱氧-β-L-胞苷（β-L-ddC）在体外对乙型肝炎病毒和1型人类免疫缺陷病毒的抗病毒活性。

Biochem Pharmacol. 1994 Jan 20;47(2):171-4. doi: 10.1016/0006-2952(94)90002-7.

Synthesis and comparative evaluation of two antiviral agents: beta-L-Fd4C and beta-D-Fd4C.两种抗病毒药物：β-L-Fd4C和β-D-Fd4C的合成与比较评估

Bioorg Med Chem Lett. 1998 Nov 17;8(22):3245-50. doi: 10.1016/s0960-894x(98)00599-x.

Anti-hepatitis B virus activity and metabolism of 2',3'-dideoxy-2',3'-didehydro-beta-L(-)-5-fluorocytidine.2',3'-二脱氧-2',3'-二脱氢-β-L(-)-5-氟胞苷的抗乙型肝炎病毒活性及代谢

Antimicrob Agents Chemother. 1998 Jul;42(7):1805-10. doi: 10.1128/AAC.42.7.1805.

Immunomodulatory and antiviral activities of 2',3'-dideoxy-beta-L-cytidine and 2',3'-dideoxy-beta-L-5-fluorocytidine.2',3'-二脱氧-β-L-胞苷和2',3'-二脱氧-β-L-5-氟胞苷的免疫调节和抗病毒活性。

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Antiviral activity of beta-L-2',3'-dideoxy-2',3'-didehydro-5-fluorocytidine in woodchucks chronically infected with woodchuck hepatitis virus.β-L-2',3'-二脱氧-2',3'-二脱氢-5-氟胞苷对慢性感染土拨鼠肝炎病毒的土拨鼠的抗病毒活性。

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Metabolism of 2',3'-dideoxy-2',3'-didehydro-beta-L(-)-5-fluorocytidine and its activity in combination with clinically approved anti-human immunodeficiency virus beta-D(+) nucleoside analogs in vitro.2',3'-二脱氧-2',3'-二脱氢-β-L(-)-5-氟胞苷的代谢及其与临床批准的抗人免疫缺陷病毒β-D(+)核苷类似物联合应用时的体外活性

Antimicrob Agents Chemother. 1998 Jul;42(7):1799-804. doi: 10.1128/AAC.42.7.1799.

Characterization of the antiviral effect of 2',3'-dideoxy-2', 3'-didehydro-beta-L-5-fluorocytidine in the duck hepatitis B virus infection model.2',3'-二脱氧-2',3'-二脱氢-β-L-5-氟胞苷在鸭乙型肝炎病毒感染模型中的抗病毒作用特性

Antimicrob Agents Chemother. 2000 Jan;44(1):111-22. doi: 10.1128/AAC.44.1.111-122.2000.

N4-acyl-modified D-2',3'-dideoxy-5-fluorocytidine nucleoside analogues with improved antiviral activity.具有改善抗病毒活性的N4-酰基修饰的D-2',3'-二脱氧-5-氟胞苷核苷类似物。

Antivir Chem Chemother. 2003 Mar;14(2):81-90. doi: 10.1177/095632020301400203.

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