两种抗病毒药物：β-L-Fd4C和β-D-Fd4C的合成与比较评估
Synthesis and comparative evaluation of two antiviral agents: beta-L-Fd4C and beta-D-Fd4C.
作者信息
Chen S H, Lin S, King I, Spinka T, Dutschman G E, Gullen E A, Cheng Y C, Doyle T W
机构信息
Vion Pharmaceuticals, Inc., Four Science Park, New Haven, CT 06511, USA.
出版信息
Bioorg Med Chem Lett. 1998 Nov 17;8(22):3245-50. doi: 10.1016/s0960-894x(98)00599-x.
PMID:9873711
Abstract
The synthesis of beta-D-Fd4C was achieved in a stereoselective fashion from D-xylose. The antiviral activity and cytotoxicity of beta-D-Fd4C was compared with that of beta-L-Fd4C and 3TC (Lamivudine). Of the three agents compared, beta-L-Fd4C was found to be the most potent antiviral agent.
摘要
β-D-Fd4C是通过立体选择性方式由D-木糖合成的。将β-D-Fd4C的抗病毒活性和细胞毒性与β-L-Fd4C和3TC（拉米夫定）进行了比较。在所比较的三种药物中，β-L-Fd4C被发现是最有效的抗病毒药物。
Zotero 插件