对葡萄球菌、肺炎球菌和肠球菌具有活性的（内酰胺基乙烯基）头孢菌素的合成及其构效关系
Synthesis and structure-activity relationship of (lactamylvinyl)cephalosporins exhibiting activity against staphylococci, pneumococci, and enterococci.
作者信息
Heinze-Krauss I, Angehrn P, Guerry P, Hebeisen P, Hubschwerlen C, Kompis I, Page M G, Richter H G, Runtz V, Stalder H, Weiss U, Wei C C
机构信息
F. Hoffmann-La Roche Ltd., Basel, Switzerland.
出版信息
J Med Chem. 1996 Apr 26;39(9):1864-71. doi: 10.1021/jm950886v.
PMID:8627610
Abstract
The synthesis and structure-activity relationships of a new class of vinylcephalosporins substituted with a lactamyl residue are described. These compounds show excellent activity against enterococci and retain the broad spectrum activity of third-generation cephalosporins such as ceftriaxone.
摘要
描述了一类新的被内酰胺基残基取代的乙烯基头孢菌素的合成及其构效关系。这些化合物对肠球菌显示出优异的活性，并保留了第三代头孢菌素（如头孢曲松）的广谱活性。
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