CD8+CD28-淋巴细胞在人类免疫缺陷病毒特异性细胞毒性活性中占主要作用。
Predominant involvement of CD8+CD28- lymphocytes in human immunodeficiency virus-specific cytotoxic activity.
作者信息
Fiorentino S, Dalod M, Olive D, Guillet J G, Gomard E
机构信息
Laboratoire d'Immunologie des Pathologies Infectieuses et Tumorales, Unité 445 de l'Institut National de la Santé et de la Recherche Médicale, Hôpital Cochin, Paris, France.
出版信息
J Virol. 1996 Mar;70(3):2022-6. doi: 10.1128/JVI.70.3.2022-2026.1996.
Abstract
Distinct functional CD8+ T-cell populations have been observed during human immunodeficiency virus (HIV) infection. One of these functions is the inhibition of viral replication by a noncytotoxic mechanism, which was shown to be mediated by the CD8+CD28+ subpopulation. On the other hand, CD8+ T cells exert an HIV-specific cytotoxic activity. The present study shows that CD8+CD28- lymphocytes display this HIV-specific cytotoxic activity, which is detectable immediately after the cells are purified from peripheral blood. The CD28- population is also able to proliferate and to retain its cytotoxic activity after in vitro restimulation with autologous blast cells. Finally, HIV-specific cytotoxic T cells can be obtained in vitro from the CD8+CD28+ population.
摘要
在人类免疫缺陷病毒（HIV）感染期间，已观察到不同功能的CD8 + T细胞群体。其中一种功能是通过非细胞毒性机制抑制病毒复制，这一机制已被证明是由CD8 + CD28 +亚群介导的。另一方面，CD8 + T细胞具有HIV特异性细胞毒性活性。本研究表明，CD8 + CD28-淋巴细胞具有这种HIV特异性细胞毒性活性，从外周血中纯化细胞后可立即检测到。在用自体母细胞进行体外再刺激后，CD28-群体也能够增殖并保留其细胞毒性活性。最后，HIV特异性细胞毒性T细胞可在体外从CD8 + CD28 +群体中获得。
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