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What is the orientation of DNA polymerases on their templates?

作者信息

Hughes S H, Hostomsky Z, Le Grice S F, Lentz K, Arnold E

机构信息

ABL-Basic Research Program, NCI-Frederick Cancer Research and Development Center, Frederick, Maryland 21702-1201, USA.

出版信息

J Virol. 1996 May;70(5):2679-83. doi: 10.1128/JVI.70.5.2679-2683.1996.

DOI:10.1128/JVI.70.5.2679-2683.1996
PMID:8627740
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC190123/
Abstract
摘要

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Human immunodeficiency virus type 1 nucleocapsid protein can prevent self-priming of minus-strand strong stop DNA by promoting the annealing of short oligonucleotides to hairpin sequences.1型人类免疫缺陷病毒核衣壳蛋白可通过促进短寡核苷酸与发夹序列的退火来阻止负链强终止DNA的自身引发。
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Human recombinant antibody fragments neutralizing human immunodeficiency virus type 1 reverse transcriptase provide an experimental basis for the structural classification of the DNA polymerase family.中和人免疫缺陷病毒1型逆转录酶的人重组抗体片段为DNA聚合酶家族的结构分类提供了实验依据。
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本文引用的文献

1
Mechanistic implications from the structure of a catalytic fragment of Moloney murine leukemia virus reverse transcriptase.莫洛尼鼠白血病病毒逆转录酶催化片段结构的机制启示
Structure. 1995 Sep 15;3(9):879-92. doi: 10.1016/S0969-2126(01)00223-4.
2
Short gap-filling synthesis by DNA polymerase beta is processive.DNA聚合酶β进行的短缺口填补合成是持续的。
J Biol Chem. 1993 Jul 25;268(21):15906-11.
3
2.3 A crystal structure of the catalytic domain of DNA polymerase beta.2.3 DNA聚合酶β催化结构域的晶体结构。
Cell. 1994 Mar 25;76(6):1123-33. doi: 10.1016/0092-8674(94)90388-3.
4
Studies of gapped DNA substrate binding by mammalian DNA polymerase beta. Dependence on 5'-phosphate group.哺乳动物DNA聚合酶β与缺口DNA底物结合的研究。对5'-磷酸基团的依赖性。
J Biol Chem. 1994 Jul 8;269(27):18096-101.
5
Crystal structure of human immunodeficiency virus type 1 reverse transcriptase complexed with double-stranded DNA at 3.0 A resolution shows bent DNA.人类免疫缺陷病毒1型逆转录酶与双链DNA复合物在3.0埃分辨率下的晶体结构显示出弯曲的DNA。
Proc Natl Acad Sci U S A. 1993 Jul 1;90(13):6320-4. doi: 10.1073/pnas.90.13.6320.
6
Hydroxyl radical footprint analysis of human immunodeficiency virus reverse transcriptase-template.primer complexes.
Proc Natl Acad Sci U S A. 1993 Jul 1;90(13):5909-13. doi: 10.1073/pnas.90.13.5909.
7
Crystal structure of Thermus aquaticus DNA polymerase.嗜热水生栖热菌DNA聚合酶的晶体结构
Nature. 1995 Aug 17;376(6541):612-6. doi: 10.1038/376612a0.
8
Excision of deoxyribose phosphate residues by DNA polymerase beta during DNA repair.DNA修复过程中DNA聚合酶β对脱氧核糖磷酸残基的切除。
Science. 1995 Aug 4;269(5224):699-702. doi: 10.1126/science.7624801.
9
Crystal structure of the large fragment of Thermus aquaticus DNA polymerase I at 2.5-A resolution: structural basis for thermostability.嗜热水生栖热菌DNA聚合酶I大片段在2.5埃分辨率下的晶体结构：热稳定性的结构基础
Proc Natl Acad Sci U S A. 1995 Sep 26;92(20):9264-8. doi: 10.1073/pnas.92.20.9264.
10
Insights into DNA polymerization mechanisms from structure and function analysis of HIV-1 reverse transcriptase.从HIV-1逆转录酶的结构和功能分析洞察DNA聚合机制。
Biochemistry. 1995 Apr 25;34(16):5351-63. doi: 10.1021/bi00016a006.