某些N-烷基亚硝胺与大鼠肝脏微粒体相互作用所产生的光谱变化。
Spectral changes resulting from the interaction of some N-alkyl nitrosamines and rat liver microsomes.
作者信息
Diaz Gomez M I, Castro J A
出版信息
Experientia. 1977 May 15;33(5):643-5. doi: 10.1007/BF01946550.
PMID:862803
Abstract
Dimethyl (DMN) and diethyl nitrosamine (DEN) do not give characteristic spectral changes upon interaction with rat liver microsomes, while dipropyl (DPN) and dibutyl (DBN) nitrosamine cause type I spectral changes. The spectral binding constant is 100 mM for DPN and 1.17 mM for DBN. The maximal spectral change is 3.2 X 10(6) and 1.0 X 10(6) absorbance units per milligram protein for DPN and DBN respectively.
摘要
二甲基亚硝胺（DMN）和二乙基亚硝胺（DEN）与大鼠肝微粒体相互作用时不会产生特征性光谱变化，而二丙基亚硝胺（DPN）和二丁基亚硝胺（DBN）会引起I型光谱变化。DPN的光谱结合常数为100 mM，DBN的光谱结合常数为1.17 mM。DPN和DBN的最大光谱变化分别为每毫克蛋白质3.2×10⁶和1.0×10⁶吸光度单位。
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