化学诱变剂的体外代谢活化。II. BALB/cJ、C57BL/6J和RF/J小鼠肝脏、肾脏及肺中二甲亚硝胺和二乙亚硝胺的诱变剂形成、代谢与致癌性之间的关系。 - Suppr | 超能文献

In vitro metabolic activation of chemical mutagens. II. The relationships among mutagen formation, metabolism and carcinogenicity for dimethylnitrosamine and diethylnitrosamine in the livers, kidneys and lungs of BALB/cJ, C57BL/6J and RF/J mice.

作者信息

Weekes U, Brusick D

出版信息

Mutat Res. 1975 Jun;31(3):175-83. doi: 10.1016/0165-1161(75)90087-4.

DOI:10.1016/0165-1161(75)90087-4

Abstract

摘要

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In vitro metabolic activation of chemical mutagens. II. The relationships among mutagen formation, metabolism and carcinogenicity for dimethylnitrosamine and diethylnitrosamine in the livers, kidneys and lungs of BALB/cJ, C57BL/6J and RF/J mice.化学诱变剂的体外代谢活化。II. BALB/cJ、C57BL/6J和RF/J小鼠肝脏、肾脏及肺中二甲亚硝胺和二乙亚硝胺的诱变剂形成、代谢与致癌性之间的关系。

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Effects of cytochrome p-448 and p-450 inducers on microsomal dimethylnitrosamine demethylase activity and the capacity of isolated microsomes to activate dimethylnitrosamine to a mutagen.细胞色素P - 448和P - 450诱导剂对微粒体二甲基亚硝胺脱甲基酶活性以及分离的微粒体将二甲基亚硝胺激活为诱变剂能力的影响。

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Kinetic studies on the hepatic microsomal metabolism of dimethylnitrosamine, diethylnitrosamine, and methylethylnitrosamine in the rat.大鼠肝脏微粒体对二甲基亚硝胺、二乙基亚硝胺和甲基乙基亚硝胺代谢的动力学研究。

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Alcoholdehydrogenase as an activating enzyme for N-nitrosodiethanolamine (NDELA): in vitro activation of NDELA to a potent mutagen in Salmonella typhimurium.乙醇脱氢酶作为N-亚硝基二乙醇胺（NDELA）的激活酶：NDELA在体外被激活成为鼠伤寒沙门氏菌中的一种强效诱变剂。

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