Love W G, Duk S, Biolo R, Jori G, Taylor P W
Ciba Pharmaceuticals, Horsham, West Sussex, UK.
Photochem Photobiol. 1996 May;63(5):656-61. doi: 10.1111/j.1751-1097.1996.tb05670.x.
CGP55847, liposomal zinc(II)-phthalocyanine (Zn-Pc), was administered by the intravenous route to Swiss mice bearing intramuscularly implanted Ehrlich carcinomas or to C57/BL6 mice bearing subcutaneously implanted B16 melanomas. Tumors were removed 3 h or 24 h after dosing the intratumoral distribution determined by fluorescence microscopy. Localization of the photosensitizer occurred more rapidly in the Ehrlich carcinoma than in the B16 melanoma; this difference in photosensitizer uptake may be related to a higher degree of vascularization of the carcinoma. The photosensitizer was found in association with blood vessels at 3 h but not 24 h after dosing and appeared to have a greater affinity for areas of tissue necrosis within the tumor compared to viable tumor tissue. Little or no Zn-Pc was detected in the muscle tissue invaded by the Ehrlich carcinoma and was associated with the membranes and the cytosol, but not the nucleus, of cells in both tumors.
CGP55847，脂质体锌（II）-酞菁（Zn-Pc），通过静脉途径给予肌肉内植入艾氏癌的瑞士小鼠或皮下植入B16黑色素瘤的C57/BL6小鼠。给药后3小时或24小时切除肿瘤，通过荧光显微镜确定肿瘤内分布。光敏剂在艾氏癌中的定位比在B16黑色素瘤中更快；这种光敏剂摄取的差异可能与癌更高程度的血管化有关。给药后3小时在血管中发现了光敏剂，但24小时未发现，并且与存活肿瘤组织相比，光敏剂似乎对肿瘤内的组织坏死区域具有更大的亲和力。在被艾氏癌侵袭的肌肉组织中几乎未检测到Zn-Pc，并且它与两种肿瘤细胞的膜和细胞质溶胶相关，但与细胞核无关。
