Llovera M, Carbó N, García-Martínez C, Costelli P, Tessitore L, Baccino F M, Agell N, Bagby G J, López-Soriano F J, Argilés J M
Departament de Bioquímica i Biologia Molecular, Universitat de Universitat de Barcelona, Spain.
Biochem Biophys Res Commun. 1996 Apr 25;221(3):653-5. doi: 10.1006/bbrc.1996.0651.
Implantation of the ascitic tumour Yoshida AH-130 hepatoma (a cachectic tumour) resulted in important increases in muscle ubiquitin gene expression. Administration of daily injections of 25 mg/kg b.w. polyclonal goat anti-murine TNF IgG preparation to tumour-bearing rats abolished the increase in muscle ubiquitin gene expression observed in the control (non-anti-TNF-treated) tumour-bearing rats. It is concluded that TNF can have an important role in the activation of the ubiquitin-dependent proteolytic system during tumour growth.
植入腹水瘤吉田AH - 130肝癌（一种恶病质肿瘤）导致肌肉泛素基因表达显著增加。给荷瘤大鼠每日注射25mg/kg体重的多克隆山羊抗小鼠TNF IgG制剂，可消除在对照（未用抗TNF治疗）荷瘤大鼠中观察到的肌肉泛素基因表达增加。结论是，TNF在肿瘤生长过程中对泛素依赖性蛋白水解系统的激活可能起重要作用。
