Montgomery H E, Clarkson P, Nwose O M, Mikailidis D P, Jagroop I A, Dollery C, Moult J, Benhizia F, Deanfield J, Jubb M, World M, McEwan J R, Winder A, Humphries S
Hatter Institute for Cardiovascular Studies, Department of Cardiology, University College London Medical School, UK.
Arterioscler Thromb Vasc Biol. 1996 Mar;16(3):386-91. doi: 10.1161/01.atv.16.3.386.
We have investigated the effects of chronic physical training and acute intensive exercise on plasma fibrinogen levels and the relationship of these responses to beta-fibrinogen G-453-A polymorphism genotype. One hundred fifty-six male British Army recruits were studied at the start of their 10-week basic training, which emphasizes physical fitness. Cohorts were restudied between 0.5 and 5 days after a major 2-day strenuous military exercise (ME) undertaken in their final week of training. Changes in fibrinogen concentration were adjusted for the effects of age, body mass index, and smoking history. Compared with baseline values, fibrinogen concentrations were significantly lower (11.9%, P=.04) at day 5 after ME, consistent with the beneficial effect of training. However, they were higher on days 1 through 3 after ME (suggesting an "acute-phase" response to strenuous exercise) and were maximal on days 1 and 2 (27.2%, P<.001 and 37.1%, P<.001 respectively). Fibrinogen genotype was available in 149 individuals. As expected from previous studies, men with one or more fibrinogen gene A-453 alleles had plasma fibrinogen concentration slightly but significantly higher at baseline (4.5%, P=.11). During the acute-phase response (days 2 and 3), however, the degree of rise was strongly related to the presence of the A allele, being 26.7+/-5.4% (mean+/-SE), 36.5+/-11.0%, and 89.2+/-30.7 for the GG, GA, and AA genotypes, respectively (P=.01). These results confirm that chronic exercise training lowers plasma fibrinogen levels, that intensive exercise generates an acute-phase rise in levels, and that this acute response is strongly influenced by the G/A polymorphism of the beta-fibrinogen gene.
我们研究了长期体育锻炼和急性高强度运动对血浆纤维蛋白原水平的影响，以及这些反应与β-纤维蛋白原G-453-A多态性基因型的关系。156名英国陆军男性新兵在为期10周的基础训练开始时接受了研究，该训练强调身体素质。在训练最后一周进行了为期2天的高强度军事演习（ME）后的0.5至5天内，对各队列进行了再次研究。对纤维蛋白原浓度的变化进行了年龄、体重指数和吸烟史影响的校正。与基线值相比，ME后第5天纤维蛋白原浓度显著降低（11.9%，P = 0.04），这与训练的有益效果一致。然而，在ME后的第1至3天，纤维蛋白原浓度较高（提示对剧烈运动的“急性期”反应），且在第1天和第2天达到最高（分别为27.2%，P < 0.001和37.1%，P < 0.001）。149名个体的纤维蛋白原基因型数据可用。正如先前研究所预期的，携带一个或多个纤维蛋白原基因A-453等位基因的男性在基线时血浆纤维蛋白原浓度略高但显著升高（4.5%，P = 0.11）。然而，在急性期反应（第2天和第3天）期间，升高程度与A等位基因的存在密切相关，GG、GA和AA基因型的升高程度分别为26.7±5.4%（平均值±标准误）、36.5±11.0%和89.2±30.7%（P = 0.01）。这些结果证实，长期运动训练可降低血浆纤维蛋白原水平，高强度运动会使纤维蛋白原水平产生急性期升高，且这种急性反应受β-纤维蛋白原基因G/A多态性的强烈影响。
