Deshpande S G, Kandhari K C, Narang B S, Bikhchandani R, Bhutani L K
Dermatologica. 1977;154(5):284-90. doi: 10.1159/000251083.
The effect of ethanol, phenobarbitone, griseofulvin or chloroquine on 3,4-diethoxycarbonyl-1,4-dihydrocollidine (DDC)-induced porphyria in rats has been studied in experiments lasting up to 40 days. Ethanol, phenobarbitone or griseofulvin given later, in addition to DDC, resulted in a clearly greater porphyrin excretion and liver porphyrin concentration than with DDC alone. Chloroquine at first increased, then decreased porphyrin excretion and liver porphyrin was lowered. No drug without DDC was porphyrogenic.
在长达40天的实验中，研究了乙醇、苯巴比妥、灰黄霉素或氯喹对3,4 - 二乙氧基羰基 - 1,4 - 二氢可力丁（DDC）诱导的大鼠卟啉症的影响。除DDC外，后期给予乙醇、苯巴比妥或灰黄霉素，导致卟啉排泄和肝脏卟啉浓度明显高于单独使用DDC时。氯喹起初增加卟啉排泄，随后减少，肝脏卟啉含量降低。没有DDC时，没有一种药物具有致卟啉症作用。
