Makarenko N A
Lik Sprava. 1995 May-Jun(5-6):140-4.
A substantial decrease in the sympathoadrenal system catecholamines was found to be the case in muscular fatigue (the animals were running on a treadmill to refusal), as evidenced by experimental studies on white rats. Sympatholytics bring about marked reduction in the catecholamine content in hypothalamus, cerebral hemispheres and the heart, which fact contributes to the development of muscular fatigue. That this is really the case is indicated by a substantial shortening of time during which the animals were running until they came to be at the end of their tether subsequent upon administration of raucedil (2.5 mg/kg), (from 2 h 58 min. to 12 min). Fatigue was found out to be manifest as a result of the sympathoadrenal system reserves depletion.
对白鼠的实验研究表明，在肌肉疲劳（动物在跑步机上跑到力竭）的情况下，交感肾上腺系统儿茶酚胺显著减少。交感神经阻滞剂会使下丘脑、大脑半球和心脏中的儿茶酚胺含量显著降低，这一事实有助于肌肉疲劳的发展。在给予劳地洛尔（2.5毫克/千克）后，动物跑到力竭的时间大幅缩短（从2小时58分钟缩短至12分钟），这表明情况确实如此。疲劳被发现是交感肾上腺系统储备耗竭的结果。
