Gostick N K
J Int Med Res. 1977;5(1 Suppl):2-10.
This study was a multicentre general practitioner trial comparing four dosage regimes of clomipramine (Anafranil, Geigy Pharmaceuticals): 10 mg t.d.s., 30 mg o.n., 25 mg t.d.s. and 75 mg o.n. This paper concerns the clinical results obtained using a series of twelve visual analogue scales completed independently by doctor and patient. Also side-effects, recorded on a standard list of unwanted effects of tricyclic antidepressants, were studied. Very few statistical differences were found between the dosage regimes, and they were difficult to interpret clinically. It was concluded that although 25 mg t.d.s. was most effective, 30 mg o.n. was probably the best compromise in terms of efficacy and tolerability.
本研究是一项多中心全科医生试验，比较了氯米帕明（安拿芬尼，嘉基制药公司）的四种剂量方案：每日三次，每次10毫克；每晚30毫克；每日三次，每次25毫克；每晚75毫克。本文涉及使用医生和患者独立完成的一系列十二个视觉模拟量表所获得的临床结果。同时，还研究了记录在三环类抗抑郁药不良反应标准列表上的副作用。各剂量方案之间发现的统计学差异极少，且在临床上难以解释。得出的结论是，虽然每日三次，每次25毫克最为有效，但就疗效和耐受性而言，每晚30毫克可能是最佳折衷方案。
