Seldrup J
J Int Med Res. 1977;5(1 Suppl):55-60.
In a multicentre general practitioner trial, in which patients were treated with various dose regimes of clomipramine (Anafranil, Geigy Pharmaceuticals), patients and doctors completed independently of each other a series of visual analogue scales on admission and after one, two and four weeks of treatment. A regression technique is described to deal with the comparison between patient and doctor completed scales. It is suggested that this method is more informative than just giving correlations between ratings. The study shows that for the two target symptoms, depression and anxiety, the agreement between patient and doctor ratings is poor, particularly at the beginning of the study. The 'best' results are obtained for initial sleep, appetite and libido. Some explanations for these findings are offered, and further researches of the visual analogue scale are suggested.
在一项多中心全科医生试验中，患者接受了不同剂量方案的氯米帕明（安拿芬尼，瑞士汽巴嘉基制药公司）治疗，患者和医生在入院时以及治疗1周、2周和4周后，分别独立完成了一系列视觉模拟量表。本文描述了一种回归技术，用于处理患者和医生完成的量表之间的比较。建议该方法比仅给出评分之间的相关性更具信息量。研究表明，对于抑郁和焦虑这两个目标症状，患者和医生的评分之间一致性较差，尤其是在研究开始时。在初始睡眠、食欲和性欲方面获得了“最佳”结果。文中对这些发现提供了一些解释，并建议对视觉模拟量表进行进一步研究。
