Chompootaweep S, Kochagarn E, Sirisumpan S, Tang-usaha J, Theppitaksak B, Dusitsin N
Department of Pharmacology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
Contraception. 1996 Jan;53(1):33-6. doi: 10.1016/0010-7824(95)00261-8.
The purpose of the study was to evaluate the efficacy, acceptability, side effects and continuation rates of the implant system in Thai women. A five-year clinical study of 308 women receiving Norplant-6 implants in Bangkok was conducted. Acceptors' mean age was 29 years, and mean number of children was about two. More than half of the users (63%) finished primary school. The cumulative continuation rates for Norplant implants at first, second, third, fourth and fifth years were, respectively, 98%, 91%, 83%, 78% and 71%. Eight out of a total of eleven pregnancies occurred in the fourth and fifth year of use. The cumulative pregnancy rate was 1.1% for the third year, 2.0% for the fourth year and 4.2% for the fifth year. Desire for future pregnancy was the leading cause for termination of Norplant implants use. The five-year cumulative termination rate for planned pregnancy was 9.2%. Disruption of menstrual rhythm, particularly increased bleeding, was the other main reason for termination; however, the prevalence of menstrual irregularities appeared to diminish with time. The cumulative termination rate for menstrual irregularities in the fifth year of the study was 4.4%. The complaints of "other medical reasons" for removal of Norplant implants were acne, severe headache, and chloasma. The five-year cumulative termination rate for other personal reasons was 7.9%. These personal reasons were husband having vasectomy, husband objection and divorce. It can be seen from this five-year study that Norplant implants are well accepted by Thai women. However, the efficacy in preventing pregnancy was not acceptable during the fourth and fifth year of use in this study, which was different from results of other international studies.
该研究的目的是评估植入系统在泰国女性中的疗效、可接受性、副作用及续用率。在曼谷对308名接受诺普兰-6型植入剂的女性进行了一项为期五年的临床研究。接受者的平均年龄为29岁，平均子女数约为两个。超过一半的使用者（63%）小学毕业。诺普兰植入剂在第一年、第二年、第三年、第四年和第五年的累积续用率分别为98%、91%、83%、78%和71%。总共11次怀孕中有8次发生在使用的第四年和第五年。第三年的累积妊娠率为1.1%，第四年为2.0%，第五年为4.2%。希望未来怀孕是终止使用诺普兰植入剂的主要原因。计划怀孕的五年累积终止率为9.2%。月经周期紊乱，尤其是出血增加，是终止使用的另一个主要原因；然而，月经不规律的发生率似乎随着时间的推移而降低。研究第五年月经不规律的累积终止率为4.4%。因“其他医学原因”取出诺普兰植入剂的主诉有痤疮、严重头痛和黄褐斑。因其他个人原因的五年累积终止率为7.9%。这些个人原因包括丈夫接受输精管切除术、丈夫反对和离婚。从这项为期五年的研究可以看出，诺普兰植入剂被泰国女性广泛接受。然而，在本研究中，该植入剂在使用的第四年和第五年预防怀孕的效果并不理想，这与其他国际研究的结果不同。
