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曼谷泰国女性使用第二代皮下埋植避孕剂(Norplant-2)的经验。

Experience of Thai women in Bangkok with Norplant-2 implants.

作者信息

Chompootaweep S, Kochagarn E, Tang-Usaha J, Theppitaksak B, Dusitsin N

机构信息

Department of Pharmacology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.

出版信息

Contraception. 1998 Oct;58(4):221-5. doi: 10.1016/s0010-7824(98)00101-2.

Abstract

A prospective study of the Norplant-2 contraceptive subdermal implant system was conducted in Bangkok, Thailand. The objective of the study was to evaluate the efficacy, adverse effects, and overall acceptability of Norplant-2 implants. A total of 140 women were enrolled in a 3-year clinical trial. The mean age was 29 years. Of all the acceptors, 70% had completed primary school. The continuation rates at years 1, 2, and 3 were, respectively, 94%, 89%, and 83%. No accidental pregnancies occurred throughout the 3 years of use in this study. Personal reasons were the leading cause for termination of Norplant-2 implant use. The 3-year cumulative termination rate for personal reasons was 7.2%. These personal reasons were divorce, husband having vasectomy, and moving away from the study area. The other leading cause for termination was medical reasons; acne, headache, and pain at the implant site were the complaints. The termination rate for medical reasons in year 3 of the study was 4.6%. Prolonged menstrual flow was the other main reason for termination. The 3-year cumulative termination rate for menstrual irregularities was 3.8%. In this study, the cumulative termination for planned pregnancy at the end of the year 3 was only 1.6%. The incidence of difficult removals was 8%. Breakage of the rods on removal was encountered in the majority of these cases. The study findings presented suggest that the Norplant-2 implants are highly effective with high continuation rates. The Norplant-2 system could become another choice of long acting reversible contraception for Thai women.

摘要

在泰国曼谷对诺普兰-2皮下避孕植入系统进行了一项前瞻性研究。该研究的目的是评估诺普兰-2植入物的有效性、不良反应和总体可接受性。共有140名女性参加了一项为期3年的临床试验。平均年龄为29岁。在所有接受者中,70%完成了小学教育。第1年、第2年和第3年的持续使用率分别为94%、89%和83%。在本研究的3年使用期内未发生意外怀孕。个人原因是终止使用诺普兰-2植入物的主要原因。因个人原因的3年累计终止率为7.2%。这些个人原因包括离婚、丈夫接受输精管切除术以及搬离研究区域。另一个主要的终止原因是医疗原因;痤疮、头痛和植入部位疼痛是常见的抱怨。研究第3年因医疗原因的终止率为4.6%。月经持续时间延长是另一个主要的终止原因。月经不规律的3年累计终止率为3.8%。在本研究中,第3年末因计划怀孕的累计终止率仅为1.6%。取出困难的发生率为8%。在大多数这些病例中,取出时遇到棒体断裂。研究结果表明,诺普兰-2植入物非常有效且持续使用率高。诺普兰-2系统可能成为泰国女性长效可逆避孕的另一种选择。

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