Godsland I F
Division of Metabolic Medicine, National Heart and Lung Institute, Imperial College, London, UK.
Contraception. 1996 Jan;53(1):9-16. doi: 10.1016/0010-7824(95)00260-x.
An analysis was undertaken to determine whether combined oral contraceptive (OC) use interacts with the effects of potential cardiovascular risk modifiers (age, body mass index, cigarette smoking, alcohol intake, exercise habit, family histories of heart disease or diabetes, number of pregnancies and duration of OC use) on blood pressure and lipid, lipoprotein, glucose and insulin risk markers for cardiovascular disease. Relationships between risk modifiers and risk markers were compared between non-users (n = 418) and users of low-estrogen dose OC (n = 925, categorised according to progestin content as monophasic levonorgestrel, triphasic levonorgestrel, norethindrone or desogestrel). OC use diminished the adverse effects of age on glucose tolerance. Aerobic exercise had a particularly beneficial effect on triglyceride levels and OGTT insulin response in OC users. The rise in HDL and HDL2 cholesterol concentrations with alcohol intake seen in non-users was diminished in OC users. Increasing duration of use of a desogestrel combination was associated with increasing HDL cholesterol concentrations. No adverse effects of risk modifiers on metabolic risk markers and blood pressure were augmented by OC use, and some were even diminished.
开展了一项分析，以确定联合口服避孕药（OC）的使用是否会与潜在心血管风险调节因素（年龄、体重指数、吸烟、饮酒、运动习惯、心脏病或糖尿病家族史、怀孕次数和OC使用时长）对血压以及心血管疾病的血脂、脂蛋白、血糖和胰岛素风险标志物的影响产生相互作用。比较了未使用者（n = 418）与低雌激素剂量OC使用者（n = 925，根据孕激素含量分为单相左炔诺孕酮、三相左炔诺孕酮、炔诺酮或去氧孕烯）之间风险调节因素与风险标志物的关系。使用OC可减轻年龄对葡萄糖耐量的不良影响。有氧运动对OC使用者的甘油三酯水平和口服葡萄糖耐量试验胰岛素反应具有特别有益的作用。在未使用者中观察到的饮酒导致的高密度脂蛋白（HDL）和HDL2胆固醇浓度升高，在OC使用者中有所减弱。使用去氧孕烯复方制剂的时长增加与HDL胆固醇浓度升高相关。OC的使用并未增强风险调节因素对代谢风险标志物和血压的不良影响，有些影响甚至减弱了。
