原位分离灌注大鼠胰腺：一种用于外分泌胰腺药理学研究的新方法。
In-situ-isolated perfused rat pancreas: a new method for pharmacological studies of the exocrine pancreas.
作者信息
Tournut R, Estival A, Vaysse N, Pascal J P, Ribet A
出版信息
Digestion. 1977;15(4):329-37. doi: 10.1159/000198019.
PMID:863135
Abstract
A method of in-situ-isolated perfused rat pancreas is described. In situ perfusion of the isolated rat pancreas allows a faster set-up, thanks to a simpler operating procedure. The sensitivity of the isolated rat pancreas has been tested with secretin and cholecystokinin. The pancreas responds to doses of secretin as low as 0.005 CU/kg-h. Such a highly sensitive model might prove to be useful for the bioassay of secretin and the study of the effects of pancreatic secretagogues.
摘要
本文描述了一种原位隔离灌注大鼠胰腺的方法。由于操作程序更简单，对分离的大鼠胰腺进行原位灌注可以更快地完成设置。已用促胰液素和缩胆囊素对分离的大鼠胰腺的敏感性进行了测试。胰腺对低至0.005 CU/kg-h剂量的促胰液素都有反应。这样一个高度敏感的模型可能被证明对促胰液素的生物测定以及胰腺促分泌剂作用的研究有用。
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In-situ-isolated perfused rat pancreas: a new method for pharmacological studies of the exocrine pancreas.原位分离灌注大鼠胰腺：一种用于外分泌胰腺药理学研究的新方法。
Digestion. 1977;15(4):329-37. doi: 10.1159/000198019.
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