β-青蒿琥酯钠——一种新的潜在杀配子体药物。
Sodium beta-artelinate--a new potential gametocytocide.
作者信息
Tripathi R, Puri S K, Dutta G P
机构信息
Division of Microbiology, Central Drug Research Institute, Lucknow, India.
出版信息
Exp Parasitol. 1996 Apr;82(3):251-4. doi: 10.1006/expr.1996.0032.
The water-soluble artemisinin analogue sodium beta-artelinate, a fast-acting blood schizontocide, was evaluated for gametocytocidal action against simian malaria Plasmodium cynomolgi B, and a single dose of the compound has been found to be an effective gametocytocide by both oral and intravenous routes. The compound was able to sterilize the circulating gametocytes in rhesus monkey, resulting in loss of mosquito infectivity and oocyst development in the Anopheles stephensi. However, no sporontocidal action has been observed with this compound.
水溶性青蒿素类似物β-青蒿琥酯钠是一种速效血液裂殖体杀灭剂，对食蟹猴疟原虫B进行了配子体杀灭作用评估，发现单剂量该化合物经口服和静脉途径均为有效的配子体杀灭剂。该化合物能够清除恒河猴体内循环的配子体，导致斯氏按蚊失去感染性且无法发育成卵囊。然而，未观察到该化合物对孢子增殖体的杀灭作用。
Zotero 插件