Dutta G P, Bajpai R, Vishwakarma R A
Central Drug Research Institute, Lucknow, India.
Chemotherapy. 1989;35(3):200-7. doi: 10.1159/000238671.
Gametocytocidal activity of artemisinin (qinghaosu) has been demonstrated against simian malaria parasite Plasmodium cynomolgi B. Colony-bred Anopheles stephensi were allowed to feed on gametocyte-carrying rhesus monkeys and the mosquito infectivity rate and oocyst count of the infected mosquito gut were recorded on day 8-9 postinfection. Control (pretreatment) feedings of mosquito on gametocyte-carrying monkeys showed good infectivity in different batches of the mosquitoes ranging from 57.14 to 95.0%. Administration of single intramuscular injection of 5 mg/kg artemisinin (suspended in neutralised oil) resulted in complete loss of mosquito infectivity within 24 h of drug administration. This is the first report on the possible use of artemisinin to stop malaria transmission. The drug has no sporontocidal action.
青蒿素（青蒿琥酯）对食蟹猴疟原虫疟原虫B的配子体杀灭活性已得到证实。将群体饲养的斯氏按蚊置于携带配子体的恒河猴身上吸血，并在感染后第8 - 9天记录感染蚊子肠道的感染率和卵囊数量。对照（预处理）实验中，让蚊子吸食携带配子体的猴子血液，结果显示不同批次的蚊子感染率良好，在57.14%至95.0%之间。单次肌肉注射5毫克/千克青蒿素（悬浮于中和油中）后，给药后24小时内蚊子的感染性完全丧失。这是关于青蒿素可能用于阻止疟疾传播的首次报道。该药物没有杀孢子体作用。
