Heino J
Department of Medical Biochemistry, University of Turku, Finland.
Int J Cancer. 1996 Mar 15;65(6):717-22. doi: 10.1002/(SICI)1097-0215(19960315)65:6<717::AID-IJC1>3.0.CO;2-1.
Invasion of malignant cells requires altered cellular interaction with extracellular matrix. Integrin-type cell adhesion receptors play an important role in this process. Integrin-related cell biological phenomena explain cancer cell migration, and recent developments in the field have made it possible to propose that integrins are also involved in the penetration through basement membranes and other molecular barriers. Finally, malignant melanoma has been used here as an example to speculate on the function of each integrin in light of information from different experimental models.
恶性细胞的侵袭需要细胞与细胞外基质的相互作用发生改变。整合素型细胞黏附受体在这一过程中起重要作用。与整合素相关的细胞生物学现象解释了癌细胞的迁移，该领域的最新进展使得提出整合素也参与穿过基底膜和其他分子屏障成为可能。最后，本文以恶性黑色素瘤为例，根据来自不同实验模型的信息推测每种整合素的功能。
