氧化戊糖磷酸途径参与鼠伤寒沙门氏菌硫胺素的生物合成。
Involvement of the oxidative pentose phosphate pathway in thiamine biosynthesis in Salmonella typhimurium.
作者信息
Enos-Berlage J L, Downs D M
机构信息
Department of Bacteriology, University of Wisconsin--Madison 53706, USA.
出版信息
J Bacteriol. 1996 Mar;178(5):1476-9. doi: 10.1128/jb.178.5.1476-1479.1996.
Abstract
purF mutants of Salmonella typhimurium are known to require a source of both purine and thiamine; however, exogenous pantothenate may be substituted for the thiamine requirement. We show here that the effect of pantothenate is prevented by blocks in the oxidative pentose phosphate pathway, gnd (encoding gluconate 6-phosphate [6-P] dehydrogenase) or zwf (encoding glucose 6-P dehydrogenase). We further show that the defects caused by these mutations can be overcome by increasing ribose 5-P, suggesting that ribose 5-P may play a role in the ability of pantothenate to substitute for thiamine.
摘要
已知鼠伤寒沙门氏菌的purF突变体需要嘌呤和硫胺素来源；然而，外源性泛酸盐可替代硫胺素需求。我们在此表明，戊糖磷酸氧化途径中的阻断，即gnd（编码葡萄糖酸6-磷酸[6-P]脱氢酶）或zwf（编码葡萄糖6-P脱氢酶），可阻止泛酸盐的作用。我们进一步表明，通过增加5-磷酸核糖可克服这些突变导致的缺陷，这表明5-磷酸核糖可能在泛酸盐替代硫胺素的能力中发挥作用。
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