Teranishi S, Kitade F, Itaya H
Gastroenterol Jpn. 1977;12(1):28-35. doi: 10.1007/BF02773999.
In order to clarify the pathophysiology of digestive disorders which are caused with anticancer agents, Mitomycin C was intravenously administrated to rats and the ultrastructure of the pancreas was studied. The alteration of acinar cells after under 4 daily administrations of 1.0 mg/Kg of Mitomycin C was not remarkable and in an early stage returned to normal structure. In above 8 daily administrations of 1.0 mg/Kg of Mitomycin C, however, pronounced degeneration of acinar cells was induced and acinar cells did not recover to the previous level, but die within one month. The ultrastructural changes induced by Mitomycin C were mainly aggregation of chromatin in the nuclei, tubularly dilatation of the rough endoplasmic reticulum, and swelling of the mitochondria. It was surmised that the biosynthesis and supply of protein such as digestive enzymes were not amply carried on; hence, the ehcmotherapy could give rise to severe digestion disorders. It appeared necessary to further study the dosage and dosage schedule of the anticancer agents, along with the necessity for taking ample care of patients presenting such disorders.
为了阐明由抗癌剂引起的消化系统疾病的病理生理学，将丝裂霉素C静脉注射给大鼠，并研究胰腺的超微结构。每日给予1.0mg/kg丝裂霉素C，连续4天以下，腺泡细胞的改变不明显，且在早期可恢复正常结构。然而，每日给予1.0mg/kg丝裂霉素C，连续8天以上，可诱导腺泡细胞明显变性，腺泡细胞不能恢复到先前水平，而是在一个月内死亡。丝裂霉素C诱导的超微结构变化主要是细胞核内染色质聚集、粗面内质网呈管状扩张以及线粒体肿胀。据推测，消化酶等蛋白质的生物合成和供应不能充分进行；因此，化疗可能会引起严重的消化紊乱。似乎有必要进一步研究抗癌剂的剂量和给药方案，同时有必要对出现此类疾病的患者给予充分的护理。
