Teranishi S, Kitade F, Itaya H
Gastroenterol Jpn. 1976;11(3):182-8. doi: 10.1007/BF02777702.
In order to make clear the pathophysiology of digestive symptoms which are caused with anticancer agents, three anticancer agents, i.e., mitomycin C, 5-FU and cytosine arabinoside were administered pre-operatively, and the ultrastructure of the intestinal epithelium, especially that of absorptive cells, were studied on the specimens collected intra-operatively. In view of the finding that severe degeneration occurred inside cytoplasms, chiefly their nuclei, it was surmised that the biosynthesis and supply of proteins such as digestive enzymes were not amply carried on; hence, the chemotherapy could give rise to severe digestion and absorption disorders. It appeared necessary to further study the dosage and dosage schedule of the anticancer agents, along with the necessity for taking ample care of patients presenting such disorders.
为了明确抗癌药物所引起的消化症状的病理生理学，术前给予了三种抗癌药物，即丝裂霉素C、5-氟尿嘧啶和阿糖胞苷，并对术中采集的标本研究了肠上皮，尤其是吸收细胞的超微结构。鉴于在细胞质内，主要是细胞核内发生了严重变性这一发现，推测消化酶等蛋白质的生物合成和供应未充分进行；因此，化疗可导致严重的消化和吸收障碍。似乎有必要进一步研究抗癌药物的剂量和给药方案，同时有必要对出现此类障碍的患者给予充分护理。
