核糖胍的设计与合成：RNA的一种聚阳离子类似物。
Design and synthesis of ribonucleic guanidine: a polycationic analog of RNA.
作者信息
Dempcy R O, Luo J, Bruice T C
机构信息
Department of Chemistry, University of California, Santa Barbara 93106, USA.
出版信息
Proc Natl Acad Sci U S A. 1996 Apr 30;93(9):4326-30. doi: 10.1073/pnas.93.9.4326.
Abstract
Replacement of the phosphodiester linkages of the polyanion RNA with guanidinium linkers (represented by g) provides the polycation ribonucleic guanidine (RNG). An anticipated structure for the triple-helical hybrid [r(Up)9U.r(Ag)9A.r(Up)9U] is presented. A basic strategy for the synthesis of RNG oligomers is described. Synthetic procedures are provided for tetrameric adenosyl RNG [r(Ag)3A].
摘要
用胍基连接体（用g表示）取代聚阴离子RNA的磷酸二酯键可得到聚阳离子核糖核酸胍（RNG）。给出了三螺旋杂合体[r(Up)9U.r(Ag)9A.r(Up)9U]的预期结构。描述了合成RNG寡聚物的基本策略。提供了四聚腺苷基RNG[r(Ag)3A]的合成步骤。
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2
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