Fried M, Duffy P E
U.S. Army Medical Research Unit-Kenya, Kisumu.
Science. 1996 Jun 7;272(5267):1502-4. doi: 10.1126/science.272.5267.1502.
Women are particularly susceptible to malaria during first and second pregnancies, even though they may have developed immunity over years of residence in endemic areas. Plasmodium falciparum-infected red blood cells (IRBCs) were obtained from human placentas. These IRBCs bound to purified chondroitin sulfate A (CSA) but not to other extracellular matrix proteins or to other known IRBC receptors. IRBCs from nonpregnant donors did not bind to CSA. Placental IRBCs adhered to sections of fresh-frozen human placenta with an anatomic distribution similar to that of naturally infected placentas, and this adhesion was competitively inhibited by purified CSA. Thus, adhesion to CSA appears to select for a subpopulation of parasites that causes maternal malaria.
女性在首次和第二次怀孕时特别容易感染疟疾，尽管她们可能在流行地区居住多年后已产生免疫力。恶性疟原虫感染的红细胞（IRBCs）取自人类胎盘。这些IRBCs与纯化的硫酸软骨素A（CSA）结合，但不与其他细胞外基质蛋白或其他已知的IRBC受体结合。来自未怀孕供体的IRBCs不与CSA结合。胎盘IRBCs黏附于新鲜冷冻的人类胎盘切片，其解剖分布与自然感染的胎盘相似，且这种黏附被纯化的CSA竞争性抑制。因此，对CSA的黏附似乎选择了导致孕妇疟疾的寄生虫亚群。
