Department of Veterinary Medical Sciences, University of Bologna, Ozzano dell'Emilia, 40064 Bologna, Italy.
Department of Biology and Biotechnology, University of Pavia, 27100 Pavia, Italy.
Int J Mol Sci. 2022 Mar 17;23(6):3253. doi: 10.3390/ijms23063253.
Multiple Sclerosis is a chronic neurological disease characterized by demyelination and axonal loss. This pathology, still largely of unknown etiology, carries within it a complex series of etiopathogenetic components of which it is difficult to trace the origin. An inflammatory state is likely to be the basis of the pathology. Crucial elements of the inflammatory process are the interactions between platelets and mast cells as well as the bacterial component of the intestinal microbiota. In addition, the involvement of mast cells in autoimmune demyelinating diseases has been shown. The present work tries to hang up on that Ariadne's thread which, in the molecular complexity of the interactions between mast cells, platelets, microbiota and inflammation, characterizes Multiple Sclerosis and attempts to bring the pathology back to the causal determinism of psychopathological phenomenology. Therefore, we consider the possibility that the original error of Multiple Sclerosis can be investigated in the genetic origin of the depressive pathology.
多发性硬化症是一种慢性神经系统疾病，其特征是脱髓鞘和轴突丢失。这种病理学仍然在很大程度上病因不明，它包含了一系列复杂的病因发病机制成分，很难追溯其起源。炎症状态可能是病理学的基础。炎症过程的关键因素是血小板和肥大细胞之间的相互作用以及肠道微生物组的细菌成分。此外，已经表明肥大细胞参与自身免疫性脱髓鞘疾病。本工作试图在肥大细胞、血小板、微生物群和炎症之间相互作用的分子复杂性上找到那根阿里阿德涅线，它将多发性硬化症联系起来，并试图将病理学回归到心理病理学现象学的因果决定论。因此，我们认为，多发性硬化症的原始错误可能存在于抑郁病理的遗传起源中。
