Kawaguchi H, Haruma K, Komoto K, Yoshihara M, Sumii K, Kajiyama G
First Department of Internal Medicine, Hiroshima University School of Medicine, Japan.
Am J Gastroenterol. 1996 May;91(5):959-62.
To evaluate the association of both Helicobacter pylori (Hp) infection and advancing age with increased prevalence of atrophic gastritis.
Two hundred and thirty-eight subjects who had no esophagitis, peptic ulcers, or malignancies in the upper gastrointestinal tract were divided into three groups according to age: group A, < 30 yr; group B, 30-49 yr; group C, > or = 50 yr. Two biopsy specimens were obtained from the lesser curvature of the antrum and two from the anterior and posterior walls of the fundus to assess the degree of gastritis and histological evidence of Hp infection. Hp infection was evaluated by Giemsa staining and serum IgG antibodies. Serum gastrin (SG) and pepsinogen (PG) were determined by radioimmunoassay.
In all age groups, the prevalence of atrophic gastritis was significantly more common in subjects with evidence of Hp infection. In Hp-positive subjects, the prevalence of atrophic gastritis increased with advancing age. Atrophic gastritis was extremely rare, regardless of age, in Hp-uninfected patients. SG increased, and PG I and the PG I:II ratio decreased with age in Hp-positive subjects. This trend was not apparent in Hp-negative subjects.
Our results suggest that Hp infection is a stronger predictor than advancing age for atrophic gastritis.
评估幽门螺杆菌（Hp）感染及年龄增长与萎缩性胃炎患病率增加之间的关联。
将238例无上消化道食管炎、消化性溃疡或恶性肿瘤的受试者按年龄分为三组：A组，年龄<30岁；B组，年龄30 - 49岁；C组，年龄≥50岁。从胃窦小弯处取两块活检标本，从胃底前壁和后壁取两块活检标本，以评估胃炎程度及Hp感染的组织学证据。通过吉姆萨染色和血清IgG抗体评估Hp感染情况。采用放射免疫分析法测定血清胃泌素（SG）和胃蛋白酶原（PG）。
在所有年龄组中，有Hp感染证据的受试者萎缩性胃炎患病率明显更高。在Hp阳性受试者中，萎缩性胃炎患病率随年龄增长而增加。在未感染Hp的患者中，无论年龄大小，萎缩性胃炎都极为罕见。在Hp阳性受试者中，SG升高，PG I及PG I:II比值随年龄下降。在Hp阴性受试者中，这种趋势不明显。
我们的结果表明，对于萎缩性胃炎，Hp感染比年龄增长是更强的预测因素。
