Jiang Jian-Xia, Liu Qing, Mao Xin-Yi, Zhang Hai-Han, Zhang Guo-Xin, Xu Shun-Fu
Department of Gastroenterology, The First Affiliated Hospital of Nanjing Medical University, No. 300, Guangzhou Road, Nanjing, 210029 China.
Department of Gastroenterology, Sir Run Run Hospital Nanjing Medical University, No. 109, Longmian Road, Nanjing, 211199 China.
Springerplus. 2016 Sep 19;5(1):1601. doi: 10.1186/s40064-016-3185-2. eCollection 2016.
This present study aims to determine trends in the prevalence of H. pylori infections in Southeastern China between 2003 and 2012, and investigate corresponding changes in the prevalence of upper gastrointestinal diseases. This retrospective study screened 196,442 patients with a mean age of 47.49 ± 14.47 years (age range 5-100 years) in Southeastern China, and a total of 134,812 cases of an endoscopy-referral patient population with digestive symptoms between 2003 and 2012 were enrolled. Based on esophago-gastro-duodenoscopy and pathology, patients diagnosed with chronic gastritis, peptic ulcer, gastric cancer or reflux esophagitis were included in this study. Basic demographic and clinical characteristics such as H. pylori infection status and endoscopic findings were collected and analyzed. Among the 134,812 subjects, mean prevalence of H. pylori infection was 31.97 %; which demonstrated a linear downward trend from 42.40 to 23.82 % (P < 0.001) at an annual rate of 2 % from 2003 to 2012. Similarly, the prevalence of duodenal and gastric ulcer rapidly decreased from 12.65 to 6.57 % and from 7.51 to 3.78 %, respectively; while the prevalence of gastric cancer (from 3.76 to 2.34 %) did not significantly change in the same time period. In contrast, the prevalence of reflux esophagitis increased from 6.19 to 12.80 %. The progressively decreasing prevalence of H. pylori infections from 2003 to 2012 in Southeastern China appears to be linked with the decline of related upper gastrointestinal diseases and increase of some gastrointestinal motility diseases.
本研究旨在确定2003年至2012年中国东南部幽门螺杆菌感染率的变化趋势，并调查上消化道疾病患病率的相应变化。这项回顾性研究对中国东南部196,442名平均年龄为47.49±14.47岁（年龄范围5 - 100岁）的患者进行了筛查，共纳入了2003年至2012年间134,812例有消化症状的内镜转诊患者。基于食管-胃-十二指肠镜检查及病理结果，本研究纳入了诊断为慢性胃炎、消化性溃疡、胃癌或反流性食管炎的患者。收集并分析了基本人口统计学和临床特征，如幽门螺杆菌感染状况及内镜检查结果。在这134,812名受试者中，幽门螺杆菌感染的平均患病率为31.97%；从2003年到2012年呈线性下降趋势，从42.40%降至23.82%（P<0.001），年下降率为2%。同样，十二指肠溃疡和胃溃疡的患病率分别从12.65%迅速降至6.57%和从7.51%降至3.78%；而同期胃癌的患病率（从3.76%降至2.34%）没有显著变化。相比之下，反流性食管炎的患病率从6.19%升至12.80%。2003年至2012年中国东南部幽门螺杆菌感染率的逐渐下降似乎与相关上消化道疾病的减少及一些胃肠动力疾病的增加有关。
