Marques-Vidal P, Ducimetière P, Evans A, Cambou J P, Arveiler D
MONICA-Toulouse, Institut National de la Santé et de la Recherche Médicale (INSERM) U326, France.
Am J Epidemiol. 1996 Jun 1;143(11):1089-93. doi: 10.1093/oxfordjournals.aje.a008683.
The effect of alcohol consumption was assessed in 561 men with myocardial infarction and 643 healthy controls recruited from France and Northern Ireland between 1988 and 1991 in the ECTIM Study (Enquête Cas-Témoins de I'Infarctus du Myocarde). In total, patients consumed less wine than did controls, while non-wine-derived alcohol consumption did not differ significantly. After adjustment for cardiovascular risk factors and country of recruitment by logistic regression, alcohol consumption displayed a protective effect against myocardial infarction, the magnitude of which was comparable in both countries. This effect, which was essentially due to wine consumption in France and to nonwine consumption in Northern Ireland, was largely attenuated by the introduction of high density lipoprotein cholesterol into the model. Thus, both wine and nonwine consumption appear to exert a protective effect against myocardial infarction which is partly mediated through an increase in high density lipoprotein cholesterol.
在1988年至1991年间于ECTIM研究（心肌梗死病例对照研究）中从法国和北爱尔兰招募的561名心肌梗死男性患者和643名健康对照者中评估了饮酒的影响。总体而言，患者饮用葡萄酒的量少于对照者，而非葡萄酒类酒精饮品的消费量无显著差异。通过逻辑回归对心血管危险因素和招募国家进行调整后，饮酒对心肌梗死具有保护作用，两国的保护作用程度相当。这种作用在法国主要归因于饮用葡萄酒，在北爱尔兰则归因于饮用非葡萄酒类饮品，但在模型中引入高密度脂蛋白胆固醇后，这种作用大幅减弱。因此，饮用葡萄酒和非葡萄酒类饮品似乎都对心肌梗死具有保护作用，部分是通过增加高密度脂蛋白胆固醇来介导的。
