• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Development and validation of chromatographic methods (HPLC and GC) for the determination of the active components (benzocaine, tyrothricin and menthol) of a pharmaceutical preparation.

作者信息

Ortiz-Boyer F, Tena M T, Luque de Castro M D, Valcárcel M

机构信息

Department of Analytical Chemistry, Faculty of Sciences, University of Códoba, Spain.

出版信息

J Pharm Biomed Anal. 1995 Oct;13(11):1297-303. doi: 10.1016/0731-7085(95)01557-2.

DOI:10.1016/0731-7085(95)01557-2
PMID:8634346
Abstract

Methods are reported for the determination of tyrothricin and benzocaine by HPLC and menthol by GC in the analysis of throat lozenges (tablets) containing all three compounds. After optimization of the variables involved in both HPLC and GC the methods have been characterized and validated according to the guidelines of the Spanish Pharmacopoeia, and applied to both the monitoring of the manufacturing process and the quality control of the final product.

摘要

相似文献

1
Development and validation of chromatographic methods (HPLC and GC) for the determination of the active components (benzocaine, tyrothricin and menthol) of a pharmaceutical preparation.
J Pharm Biomed Anal. 1995 Oct;13(11):1297-303. doi: 10.1016/0731-7085(95)01557-2.
2
A rapid HPLC method for the quantification of tyrothricin, menthol, and benzocaine in pharmaceutical formulations.一种用于定量测定药物制剂中短杆菌肽、薄荷醇和苯佐卡因的快速高效液相色谱法。
J Pharm Sci. 1994 Aug;83(8):1147-9. doi: 10.1002/jps.2600830815.
3
Stability of benzocaine formulated in commercial oral disintegrating tablet platforms.商业化口腔崩解片平台中苯佐卡因的稳定性。
AAPS PharmSciTech. 2013 Dec;14(4):1333-40. doi: 10.1208/s12249-013-0015-5. Epub 2013 Aug 30.
4
A new validated method for the simultaneous determination of benzocaine, propylparaben and benzyl alcohol in a bioadhesive gel by HPLC.
J Pharm Biomed Anal. 2005 Oct 4;39(5):920-7. doi: 10.1016/j.jpba.2005.05.033. Epub 2005 Jul 20.
5
GLC analysis of menthol, phenol, benzocaine, and pyrilamine maleate in aerosol spray lotion.
J Pharm Sci. 1981 Oct;70(10):1151-2. doi: 10.1002/jps.2600701015.
6
Determination of local anesthetics in illegal products using HPLC method with amperometric detection.
Acta Pol Pharm. 2012 May-Jun;69(3):397-403.
7
Evaluation of topical pharyngeal anaesthesia by benzocaine lozenge for upper endoscopy.苯佐卡因含片用于上消化道内镜检查的咽部局部麻醉效果评估。
Aliment Pharmacol Ther. 2006 Aug 15;24(4):687-94. doi: 10.1111/j.1365-2036.2006.03023.x.
8
THE ANTIBIOTIC EFFECTIVENESS OF ORAL TROCHE THERAPY.口服含片疗法的抗生素有效性
J Med Soc N J. 1965 May;62:163-4.
9
N-bromohydantoins in pharmaceutical analysis. I. Determination of sulfonamides and some local anesthetics with 1,3-dibromo-5,5-dimethylhydantoin.药物分析中的N-溴代乙内酰脲。I. 用1,3-二溴-5,5-二甲基乙内酰脲测定磺胺类药物和一些局部麻醉剂。
J Pharm Sci. 1967 Jul;56(7):923-4. doi: 10.1002/jps.2600560736.
10
Green HPTLC and stability-indicating RP-HPLC for the assay of dextromethorphan hydrobromide and menthol in their lozenges.采用绿色高效薄层色谱法（HPTLC）和反相高效液相色谱法（RP-HPLC）对其含片中氢溴酸右美沙芬和薄荷醇进行测定及稳定性考察。
Ann Pharm Fr. 2020 Sep;78(5):368-378. doi: 10.1016/j.pharma.2020.04.006. Epub 2020 May 11.