Sheu B C, Lin H H, Chen C K, Chao K H, Shun C T, Huang S C
Department of Obstetrics and Gynecology, College of Medicine, Taipei, Taiwan.
Int J Gynaecol Obstet. 1995 Nov;51(2):141-6. doi: 10.1016/0020-7292(95)02514-d.
Synchronous carcinomas of the endometrium and ovary may indicate either independently developing neoplasms or metastatic disease. The clinical implications and prognosis of these two categories are quite different. The objectives of this study were to identify and evaluate the empirical criteria and significant therapeutic implications.
The National Taiwan University Hospital Cancer Registry records and pathological reports from 1977 to 1994 were reviewed. Empirical criteria were used to identify synchronous primary cancers.
A total of 322 patients had endometrial cancer and 421 patients had ovarian cancer in our Cancer Registry records. Eleven patients had simultaneous cancer involvement of both the endometrium and ovary. Six cases fulfilled the criteria of synchronous primary carcinomas of the endometrium and ovary. Of these, five were alive and free of disease for 35-144 months (median 94.2 months). The disease-free survival rates between patients with synchronous primary and metastatic cancers of different histologic types showed a statistically significant difference (P = 0.013). No statistical significance was noted for different histologic types (P > 0.5).
The empirical criteria used here were useful in identifying synchronous primary cancers of the endometrium and ovary. The favorable clinical outcome may relate to early detection of early-stage disease and low-grade malignancy with an indolent growth rate. Surgical management with or without adjuvant therapy has a satisfactory outcome in our experience.
子宫内膜和卵巢同时发生的癌可能提示独立发生的肿瘤或转移性疾病。这两类疾病的临床意义和预后有很大不同。本研究的目的是确定并评估经验性标准及重要的治疗意义。
回顾了台湾大学附属医院1977年至1994年的癌症登记记录和病理报告。采用经验性标准来确定同时发生的原发性癌症。
在我们的癌症登记记录中，共有322例患者患有子宫内膜癌，421例患者患有卵巢癌。11例患者同时出现子宫内膜和卵巢癌。6例符合子宫内膜和卵巢同时原发性癌的标准。其中，5例存活且无疾病35至144个月（中位94.2个月）。不同组织学类型的同时原发性癌和转移性癌患者之间的无病生存率显示出统计学显著差异（P = 0.013）。不同组织学类型未观察到统计学意义（P > 0.5）。
这里使用的经验性标准有助于识别子宫内膜和卵巢的同时原发性癌。良好的临床结果可能与早期疾病的早期发现以及低级别恶性肿瘤、生长缓慢有关。根据我们的经验，手术治疗加或不加辅助治疗都有令人满意的结果。
