三个几丁质合酶基因在白色念珠菌生长中的作用
Role of three chitin synthase genes in the growth of Candida albicans.
作者信息
Mio T, Yabe T, Sudoh M, Satoh Y, Nakajima T, Arisawa M, Yamada-Okabe H
机构信息
Department of Mycology, Nippon Roche Research Center, Kamakura, Kanagawa, Japan.
出版信息
J Bacteriol. 1996 Apr;178(8):2416-9. doi: 10.1128/jb.178.8.2416-2419.1996.
Abstract
The CHS2 and CHS3 genes of Candida albicans were disrupted. The double disruptant was still viable. Assessment of chitin and of calcofluor white resistance shows that CHS1 is responsible for septum formation and CHS3 is responsible for overall chitin synthesis otherwise. There were only small differences in virulence to immunocompromised mice of homozygous chs2 delta amd chs3 delta null mutants.
摘要
白色念珠菌的CHS2和CHS3基因被破坏。双破坏突变体仍然存活。对几丁质和对荧光增白剂抗性的评估表明，CHS1负责隔膜形成，而CHS3则负责整体几丁质合成。纯合chs2δ和chs3δ缺失突变体对免疫受损小鼠的毒力只有微小差异。
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