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巴氏梭菌丙酮酸甲酸裂解酶及其激活酶编码基因的分子特征

Molecular characterization of the genes encoding pyruvate formate-lyase and its activating enzyme of Clostridium pasteurianum.

作者信息

Weidner G, Sawers G

机构信息

Department of Microbiology and Genetics, University of Munich, Germany.

出版信息

J Bacteriol. 1996 Apr;178(8):2440-4. doi: 10.1128/jb.178.8.2440-2444.1996.

DOI:10.1128/jb.178.8.2440-2444.1996
PMID:8636053
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC177960/
Abstract

Formate is the major source of C1 units in many species of the genus Clostridium. In this study we have cloned and characterized the genes encoding pyruvate formate-lyase and its activating enzyme of Clostridium pasteurianum. The genetic and transcriptional organizations of the genes and the high level of homology exhibited by the respective gene products to their Escherichia coli counterparts indicate strong evolutionary conservation of these enzymes.

摘要

甲酸是许多梭菌属物种中一碳单位的主要来源。在本研究中，我们克隆并鉴定了巴氏梭菌中编码丙酮酸甲酸裂解酶及其激活酶的基因。这些基因的遗传和转录组织以及各自基因产物与其大肠杆菌对应物所表现出的高度同源性表明这些酶具有很强的进化保守性。

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